Linked Life Data

11111169

Source:http://linkedlifedata.com/resource/pubmed/id/11111169

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SubjectPredicateObjectContext
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pubmed-article:11111169pubmed:issue5lld:pubmed
pubmed-article:11111169pubmed:dateCreated2001-1-16lld:pubmed
pubmed-article:11111169pubmed:abstractTextLaparoscopic influence on cell-mediated immunity and tumour evolution is controversial. The objective of the present study was to assess tumour growth and immune patterns after laparoscopy on an experimental study. Lewis rats, bearing an intrapancreatic ductal carcinoma randomly underwent one of the following 2-hour procedures: anaesthesia, laparotomy or CO(2) pneumoperitoneum. Cell-mediated immunity was investigated through determination of serum IL1beta concentrations by ELISA and TNFalpha, IL6 and iNOS gene transcriptions in blood white cells and peritoneal cells by RT-PCR 1 day after operation. Tumour growth and spread patterns were assessed on anatomopathological examination 2 weeks after surgery. Tumour growth and spread were unaffected no matter what procedure was applied, but port-site seeding occurred in half of the cases undergoing laparoscopy. No significant change in acute-phase protein response, represented by IL1beta serum concentration, was found after laparoscopy. TNFalpha, IL6 and inducible NO synthase gene transcriptions were enhanced in blood white cells and depressed in peritoneal immune cells after laparoscopy. In our experimental conditions, cell-mediated immune response to CO(2) pneumoperitoneum seems to be a good systemic immune activation and a less acute peritoneal immune response as opposed to control laparoscopy. This early impairment of peritoneal macrophage immune activity, observed after a long-lasting CO(2) pneumoperitoneum, might be responsible for the high rate of port site recurrence.lld:pubmed
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pubmed-article:11111169pubmed:statusMEDLINElld:pubmed
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pubmed-article:11111169pubmed:authorpubmed-author:GurrJ AJAlld:pubmed
pubmed-article:11111169pubmed:authorpubmed-author:BastienCClld:pubmed
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pubmed-article:11111169pubmed:authorpubmed-author:WackSSlld:pubmed
pubmed-article:11111169pubmed:copyrightInfoCopyright 2000 S. Karger AG, Basellld:pubmed
pubmed-article:11111169pubmed:issnTypePrintlld:pubmed
pubmed-article:11111169pubmed:volume32lld:pubmed
pubmed-article:11111169pubmed:ownerNLMlld:pubmed
pubmed-article:11111169pubmed:authorsCompleteYlld:pubmed
pubmed-article:11111169pubmed:pagination261-6lld:pubmed
pubmed-article:11111169pubmed:dateRevised2006-11-30lld:pubmed
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pubmed-article:11111169pubmed:year2000lld:pubmed
pubmed-article:11111169pubmed:articleTitleDual effect of laparoscopy on cell-mediated immunity.lld:pubmed
pubmed-article:11111169pubmed:affiliationInstitut de Recherche contre les Cancers de l'Appareil Digestif, H opitaux Universitaires, Strasbourg, France.lld:pubmed
pubmed-article:11111169pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11111169pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed