| pubmed-article:11089576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11089576 | lifeskim:mentions | umls-concept:C0038868 | lld:lifeskim |
| pubmed-article:11089576 | lifeskim:mentions | umls-concept:C0085401 | lld:lifeskim |
| pubmed-article:11089576 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11089576 | pubmed:dateCreated | 2000-12-7 | lld:pubmed |
| pubmed-article:11089576 | pubmed:abstractText | The mechanisms leading to the abnormal self-polymerization of tau into straight and paired helical filaments (PHFs) and neurofibrillary tangles (NFT) in Alzheimer disease (AD) and progressive supranuclear palsy (PSP) are not known. However, transglutaminase-induced cross-linking of PHF-tau was observed in AD and thus may also contribute to the formation of NFT in other neurodegenerative disorders including PSP. Tissue homogenates from PSP and normal age-matched controls were used to immunoaffinity-purify proteins containing transglutaminase-induced epsilon-(gamma-glutamyl) lysine cross-links. The immunoaffinity-purified proteins were then examined on immunoblots with a PHF-tau antibody, PHF-1. There were significantly higher levels of epsilon-(gamma-glutamyl) lysine cross-linking of PHF-tau in globus pallidus and pons regions of PSP cases compared to barely detectable cross-links in controls. The occipital cortex, an area spared from neurofibrillary pathology in PSP, showed no detectable cross-linking of PHF-tau protein in either PSP cases or control cases. Double-label immunofluorescence demonstrated the colocalization of the cross-link and PHF-tau in NFT in pons of PSP Previous studies and present data are consistent with the hypothesis that transglutaminase-induced cross-linking may be a factor contributing to the abnormal polymerization and stabilization of tau in straight and PHFs leading to neurofibrillary tangle formation in neurodegenerative diseases, including PSP and AD. | lld:pubmed |
| pubmed-article:11089576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11089576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11089576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11089576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11089576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11089576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11089576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11089576 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11089576 | pubmed:issn | 0022-3069 | lld:pubmed |
| pubmed-article:11089576 | pubmed:author | pubmed-author:LeeJ MJM | lld:pubmed |
| pubmed-article:11089576 | pubmed:author | pubmed-author:TroncosoJ CJC | lld:pubmed |
| pubmed-article:11089576 | pubmed:author | pubmed-author:MumaN ANA | lld:pubmed |
| pubmed-article:11089576 | pubmed:author | pubmed-author:ZemaitaitisM... | lld:pubmed |
| pubmed-article:11089576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11089576 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:11089576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11089576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11089576 | pubmed:pagination | 983-9 | lld:pubmed |
| pubmed-article:11089576 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:meshHeading | pubmed-meshheading:11089576... | lld:pubmed |
| pubmed-article:11089576 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11089576 | pubmed:articleTitle | Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy. | lld:pubmed |
| pubmed-article:11089576 | pubmed:affiliation | Department of Pharmacology, Loyola University Chicago Medical Center, Maywood, Illinois 60153, USA. | lld:pubmed |
| pubmed-article:11089576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11089576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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