Linked Life Data

11083923

Source:http://linkedlifedata.com/resource/pubmed/id/11083923

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11083923rdf:typepubmed:Citationlld:pubmed
pubmed-article:11083923lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0001675lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0025914lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0927232lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0005516lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0013126lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0086860lld:lifeskim
pubmed-article:11083923lifeskim:mentionsumls-concept:C0205250lld:lifeskim
pubmed-article:11083923pubmed:issue5lld:pubmed
pubmed-article:11083923pubmed:dateCreated2000-12-28lld:pubmed
pubmed-article:11083923pubmed:abstractTextToward an understanding of the mechanisms controlling Preprotachykinin-A (PPTA) transcription, we introduced a 380-kb human yeast artificial chromosome containing the PPTA gene tagged with the beta-galactosidase gene into transgenic mice. This resulted in a pattern of LacZ expression in the central nervous system (CNS) remarkably similar to that reported for PPTA mRNA in the rat. However, the human gene drove expression in areas of the mouse CNS not associated with strong PPTA expression in rodents but which have been shown to express PPTA in the human. This study clearly demonstrates the high degree of conservation of the mechanisms involved in PPTA transcription that has occurred throughout 100 million of divergent human and rodent evolution. This study also defines the maximum linear extent of the human PPT-A promoter. We believe these findings constitute the removal of a significant obstacle in studying the transcriptional regulation of the human PPTA gene in vivo.lld:pubmed
pubmed-article:11083923pubmed:languageenglld:pubmed
pubmed-article:11083923pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11083923pubmed:citationSubsetIMlld:pubmed
pubmed-article:11083923pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11083923pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11083923pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11083923pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11083923pubmed:statusMEDLINElld:pubmed
pubmed-article:11083923pubmed:monthNovlld:pubmed
pubmed-article:11083923pubmed:issn1044-7431lld:pubmed
pubmed-article:11083923pubmed:authorpubmed-author:BoyleSSlld:pubmed
pubmed-article:11083923pubmed:authorpubmed-author:MacKenzieAAlld:pubmed
pubmed-article:11083923pubmed:authorpubmed-author:ClarkeA RARlld:pubmed
pubmed-article:11083923pubmed:authorpubmed-author:PayneCClld:pubmed
pubmed-article:11083923pubmed:authorpubmed-author:QuinnJ PJPlld:pubmed
pubmed-article:11083923pubmed:copyrightInfoCopyright 2000 Academic Press.lld:pubmed
pubmed-article:11083923pubmed:issnTypePrintlld:pubmed
pubmed-article:11083923pubmed:volume16lld:pubmed
pubmed-article:11083923pubmed:ownerNLMlld:pubmed
pubmed-article:11083923pubmed:authorsCompleteYlld:pubmed
pubmed-article:11083923pubmed:pagination620-30lld:pubmed
pubmed-article:11083923pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:meshHeadingpubmed-meshheading:11083923...lld:pubmed
pubmed-article:11083923pubmed:year2000lld:pubmed
pubmed-article:11083923pubmed:articleTitleThe human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS.lld:pubmed
pubmed-article:11083923pubmed:affiliationDepartment of Veterinary Pathology, Royal (Dick) School of Veterinary Studies, Summerhall Square, The University of Edinburgh, Edinburgh EH91QH, Scotland.lld:pubmed
pubmed-article:11083923pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11083923pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11083923lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11083923lld:pubmed