| pubmed-article:11082126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0025465 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C0074554 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11082126 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11082126 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11082126 | pubmed:dateCreated | 2001-2-2 | lld:pubmed |
| pubmed-article:11082126 | pubmed:abstractText | 1. Vascular effects of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, were studied in conductance (aorta) and resistance vessels (branch II or III of superior mesenteric artery, SMA) of the rat (12 - 14 weeks old). 2. Simvastatin produced relaxation of both aorta and SMA, with and without functional endothelium. These responses were inhibited by the product of HMG-CoA reductase, mevalonate (1 mmol l(-1)). 3. In vessels with functional endothelium, the NO-synthase inhibitor, L-N(G)-nitroarginine (L-NOARG, 30 micromol l(-1)), inhibited simvastatin-induced relaxation. In the presence of L-NOARG, relaxation to simvastatin was lower in vessels with endothelium than in endothelium-denuded arteries without L-NOARG. 4. The cyclo-oxygenase inhibitor, indomethacin (10 micromol l(-1)), abolished endothelium-dependent component of the response to simvastatin in both arteries. The combination of L-NOARG plus indomethacin did not produce further inhibition. The T(p) receptor antagonist, GR 32191B (3 micromol l(-1)), did not affect relaxation in aorta but it reduced response to low concentrations of simvastatin in SMA. However, the inhibitory effect of L-NOARG was less marked in the presence of GR 32191B in aorta but not in SMA. 5. The endothelium-dependent relaxation to simvastatin was inhibited by the superoxide dismutase (SOD, 100 u ml(-1)) or by the tyrosine kinase inhibitor, genistein (30 micromol l(-1)) in the two arteries. 6. The present study shows that simvastatin produces relaxation of conductance and small arteries through mevalonate-sensitive pathway. The endothelium-dependent relaxation to simvastatin involves both NO and vasodilator eicosanoids by a mechanism sensitive to SOD, and to genistein. Also, the results highlighted participation in the aorta of endothelial vasoconstrictor eicosanoids acting on the T(p) receptor after blockage of NO synthase only. | lld:pubmed |
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| pubmed-article:11082126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11082126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11082126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11082126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11082126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11082126 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11082126 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11082126 | pubmed:author | pubmed-author:MarhuendaEE | lld:pubmed |
| pubmed-article:11082126 | pubmed:author | pubmed-author:HerreraM DMD | lld:pubmed |
| pubmed-article:11082126 | pubmed:author | pubmed-author:Andriantsitoh... | lld:pubmed |
| pubmed-article:11082126 | pubmed:author | pubmed-author:Alvarez De... | lld:pubmed |
| pubmed-article:11082126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11082126 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:11082126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11082126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11082126 | pubmed:pagination | 1179-87 | lld:pubmed |
| pubmed-article:11082126 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11082126 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11082126 | pubmed:articleTitle | Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. | lld:pubmed |
| pubmed-article:11082126 | pubmed:affiliation | Department of Pharmacology, Faculty of Pharmacy, University of Seville.C/ Profesor Garcia-Gonzalez s/n, 41012 Seville, Spain. aldesoto@fafar.us.es | lld:pubmed |
| pubmed-article:11082126 | pubmed:publicationType | Journal Article | lld:pubmed |
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