| pubmed-article:11073979 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0527443 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1416963 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1419771 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0392337 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1514185 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1513143 | lld:lifeskim |
| pubmed-article:11073979 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:11073979 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:11073979 | pubmed:dateCreated | 2000-12-19 | lld:pubmed |
| pubmed-article:11073979 | pubmed:abstractText | When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth factor beta1 (TGF-beta1), terminal differentiation into myotubes is blocked. Treatment with bone morphogenetic protein 2 (BMP-2) not only blocks myogenic differentiation of C2C12 cells but also induces osteoblast differentiation. The molecular mechanisms governing the ability of TGF-beta1 and BMP-2 to both induce ligand-specific responses and inhibit myogenic differentiation are not known. We identified Runx2/PEBP2alphaA/Cbfa1, a global regulator of osteogenesis, as a major TGF-beta1-responsive element binding protein induced by TGF-beta1 and BMP-2 in C2C12 cells. Consistent with the observation that Runx2 can be induced by either TGF-beta1 or BMP-2, the exogenous expression of Runx2 mediated some of the effects of TGF-beta1 and BMP-2 but not osteoblast-specific gene expression. Runx2 mimicked common effects of TGF-beta1 and BMP-2 by inducing expression of matrix gene products (for example, collagen and fibronectin), suppressing MyoD expression, and inhibiting myotube formation of C2C12 cells. For osteoblast differentiation, an additional effector, BMP-specific Smad protein, was required. Our results indicate that Runx2 is a major target gene shared by TGF-beta and BMP signaling pathways and that the coordinated action of Runx2 and BMP-activated Smads leads to the induction of osteoblast-specific gene expression in C2C12 cells. | lld:pubmed |
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| pubmed-article:11073979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11073979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11073979 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11073979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11073979 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11073979 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:LeeK SKS | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:EBYT MTM | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:HAMR ERE | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:CookP DPD | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:KomoriTT | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:LiQ LQL | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:WozneyJ MJM | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:WildG MGM | lld:pubmed |
| pubmed-article:11073979 | pubmed:author | pubmed-author:BaeS CSC | lld:pubmed |
