Immunologic profiles of effector cells and peripheral blood stem cells mobilized with different hematopoietic growth factors.

Source:http://linkedlifedata.com/resource/pubmed/id/11072026

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Authors

Gazitt Y

Affiliation

Department of Medicine/Hematology, University of Texas, Health Science Center, San Antonio, Texas 78284, USA

Abstract

Peripheral blood stem cells (PBSC) have become the preferred source of stem cells for autologous transplantation because of the technical advantage and the shorter time to engraftment. Mobilization of CD34(+) cells into the peripheral blood can be achieved by the administration of G-CSF or GM-CSF, or both, alone or in combination with chemotherapy. G-CSF and GM-CSF differ somewhat in the number and composition of CD34(+) cells and effector cells mobilized to the peripheral blood. However, the molecular mechanism underlying the release and engraftment of CD34(+) cells is poorly understood.

PMID
11072026

Publication types

Review