| pubmed-article:11070037 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11070037 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11070037 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:11070037 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:11070037 | lifeskim:mentions | umls-concept:C0008115 | lld:lifeskim |
| pubmed-article:11070037 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11070037 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:11070037 | pubmed:dateCreated | 2000-12-4 | lld:pubmed |
| pubmed-article:11070037 | pubmed:abstractText | A molecular epidemiology study was conducted among more than 100 human immunodeficiency virus type 1 (HIV-1) subtype C seropositive intravenous drug users (IDUs) from China. Genotyping based on the envelope C2V3 coding region revealed the highest homology of the most prevalent virus strains circulating throughout China to subtype C sequences of Indian origin. Based on these results, a virtually full-length genome representing the most prevalent class of clade C strains circulating throughout China was directly amplified from peripheral blood mononuclear cells of a selected HIV-infected IDU and subcloned. Sequence analysis identified a mosaic structure, suggesting extensive intersubtype recombination events between genomes of the prevalent clade C and (B')-subtype Thai virus strains of that geographic region. Recombinant Identification Program analysis and phylogenetic bootstrapping suggested that there were 10 breakpoints (i) in the gag-pol coding region, (ii) in vpr and at the 3' end of the vpu gene, and (iii) in the nef open reading frame. (B')-sequences therefore include (i) several insertions in the gag-pol coding region; (ii) 3'-vpr, the complete vpu gene, and the first exons of tat and rev; and (iii) the 5' half of the nef gene. Breakpoints located in the vpr/vpu coding region as well as in the nef gene of 97cn54 were found at almost identical positions of all subtype C strains isolated from IDUs living in different areas of China, suggesting a common ancestor for the C/B' recombinant strains. More than 50% of well-defined subtype B-derived cytotoxic T-lymphocyte epitopes within Gag and Pol and 10% of the known epitopes in Env were found to exactly match sequences within in this clade C/B' chimeric reference strain. These results may substantially facilitate a biological comparison of clade C-derived reference strains as well as the generation of useful reagents supporting vaccine-related efforts in China. | lld:pubmed |
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| pubmed-article:11070037 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11070037 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11070037 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11070037 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11070037 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11070037 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:GrafMM | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:WagnerRR | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:WolfHH | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:MelzlHH | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:RAILG AGA | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:ZhangYY | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:TaCC | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:von BriesenHH | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:XingHH | lld:pubmed |
| pubmed-article:11070037 | pubmed:author | pubmed-author:KöstlerJJ | lld:pubmed |
| pubmed-article:11070037 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11070037 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:11070037 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11070037 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11070037 | pubmed:pagination | 11367-76 | lld:pubmed |
| pubmed-article:11070037 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11070037 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11070037 | pubmed:articleTitle | Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. | lld:pubmed |
| pubmed-article:11070037 | pubmed:affiliation | Institute of Medical Microbiology, University of Regensburg, D-93053 Regensburg, Germany. | lld:pubmed |
| pubmed-article:11070037 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11070037 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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