| pubmed-article:11060298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11060298 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11060298 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11060298 | pubmed:dateCreated | 2001-5-23 | lld:pubmed |
| pubmed-article:11060298 | pubmed:abstractText | Several signaling pathways are activated by all-trans-retinoic acid (RA) to mediate induction of differentiation and apoptosis of malignant cells. In the present study we provide evidence that the p38 MAP kinase pathway is activated in a RA-dependent manner in the NB-4, acute pro-myelocytic leukemia, and the MCF-7, breast carcinoma, cell lines. RA treatment of cells induces a time- and dose-dependent phosphorylation of p38, and such phosphorylation results in activation of its catalytic domain. p38 activation is not inducible by RA in a variant NB-4 cell line, NB-4.007/6, which is resistant to the effects of RA, suggesting a role for this pathway in the induction of RA responses. Our data also demonstrate that the small G-protein Rac1 is activated by RA and functions as an upstream regulator of p38 activation, whereas the MAPKAPK-2 serine kinase is a downstream effector for the RA-activated p38. To obtain information on the functional role of the Rac1/p38/MAPKAPK-2 pathway in RA signaling, the effects of pharmacological inhibition of p38 on RA-induced gene transcription and cell differentiation were determined. Our results indicate that treatment of cells with the SB203580 inhibitor does not inhibit RA-dependent gene transcription via retinoic acid response elements or induction of Stat1 protein expression. However, treatment with SB203580 or SB202190 strongly enhances RA-dependent induction of cell differentiation and RA-regulated growth inhibitory responses. Altogether, our findings demonstrate that the Rac1/p38 MAP kinase pathway is activated in a RA-dependent manner and exhibits negative regulatory effects on the induction of differentiation. | lld:pubmed |
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| pubmed-article:11060298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11060298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11060298 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11060298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11060298 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11060298 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:MahmudNN | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:KalvakolanuD... | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:MinucciSS | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:PlataniasL... | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:BokochGG | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:UddinSS | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:AlsayedYY | lld:pubmed |
| pubmed-article:11060298 | pubmed:author | pubmed-author:LekmineFF | lld:pubmed |
| pubmed-article:11060298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11060298 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:11060298 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11060298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11060298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11060298 | pubmed:pagination | 4012-9 | lld:pubmed |
| pubmed-article:11060298 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11060298 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11060298 | pubmed:articleTitle | Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. | lld:pubmed |
| pubmed-article:11060298 | pubmed:affiliation | Section of Hematology-Oncology, Department of Medicine, University of Illinois and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA. | lld:pubmed |
| pubmed-article:11060298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11060298 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11060298 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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