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pubmed-article:11059670pubmed:abstractTextA clearer understanding of the cellular mechanisms involved in the response to ionizing radiation is pivotal to the development of new therapeutic strategies for glioblastoma multiforme (GBM). To gain insight into dynamic functional aspects of cell cycle regulation and the control of apoptosis in GBMs, the authors investigated the molecular changes induced by ionizing radiation in genetically characterized primary GBMs in vitro compared with secondary GBMs, Grades II and III gliomas, and three GBM cell lines.lld:pubmed
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pubmed-article:11059670pubmed:articleTitleAberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53.lld:pubmed
pubmed-article:11059670pubmed:affiliationDepartment of Neuropathology, University of Marburg, Germany.lld:pubmed
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