| pubmed-article:11057907 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1166825 | lld:lifeskim |
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| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C0530129 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1336666 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:11057907 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:11057907 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11057907 | pubmed:dateCreated | 2000-11-15 | lld:pubmed |
| pubmed-article:11057907 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11057907 | pubmed:abstractText | TRAF6 is a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. We have purified a heterodimeric protein complex that links TRAF6 to IKK activation. Peptide mass fingerprinting analysis reveals that this complex is composed of the ubiquitin conjugating enzyme Ubc13 and the Ubc-like protein Uev1A. We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains. | lld:pubmed |
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| pubmed-article:11057907 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11057907 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11057907 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11057907 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11057907 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:DenkHH | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:YangLL | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:BraunAA | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:SpencerEE | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:LUY CYC | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:WangCC | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:ChenZ JZJ | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:SlaughterCC | lld:pubmed |
| pubmed-article:11057907 | pubmed:author | pubmed-author:PickartCC | lld:pubmed |
| pubmed-article:11057907 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11057907 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:11057907 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:11057907 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11057907 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11057907 | pubmed:pagination | 351-61 | lld:pubmed |
| pubmed-article:11057907 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11057907 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11057907 | pubmed:articleTitle | Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. | lld:pubmed |
| pubmed-article:11057907 | pubmed:affiliation | Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA. | lld:pubmed |
| pubmed-article:11057907 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11057907 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11057907 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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