| pubmed-article:11056374 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0121300 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0182638 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0034606 | lld:lifeskim |
| pubmed-article:11056374 | lifeskim:mentions | umls-concept:C0136946 | lld:lifeskim |
| pubmed-article:11056374 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11056374 | pubmed:dateCreated | 2000-12-15 | lld:pubmed |
| pubmed-article:11056374 | pubmed:abstractText | A quick and reproducible method for radiolabeling of Photosan-3(R), a photosensitizer used worldwide for photodynamic therapy (PDT) of cancer, with radioisotope of technetium ((99m)Tc) was developed. The radiotracer was evaluated for radiochemical purity, stability, and finally tissue distribution in a murine tumor model. The (99m)Tc-Photosan-3 prepared by using (99m)Tc-pertechnetate in place of reduced (99m)Tc demonstrated better labeling efficiency (>90%) and reproducibility. The procedure also minimized the radiation exposure to the radiochemist as handling time was considerably reduced. Due to the commercial availability of Photosan-3, the risk of batch-to-batch variation in the in situ synthesis of hematoporphyrin derivative, which is a complex mixture of at least five compounds, was also significantly reduced. The biodistribution studies and tumor scintigraphy confirmed that (99m)Tc-labeled Photosan-3 was preferentially taken up by the neoplastic tissue in a manner similar to the parent compound. In addition to applications in tumor imaging, (99m)Tc-Photosan-3 could also be used for estimating tumor uptake of Photosan-3 as may be required for individualization of clinical protocols of PDT. | lld:pubmed |
| pubmed-article:11056374 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11056374 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11056374 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11056374 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11056374 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:11056374 | pubmed:author | pubmed-author:SharmaR KRK | lld:pubmed |
| pubmed-article:11056374 | pubmed:author | pubmed-author:ChauhanU PUP | lld:pubmed |
| pubmed-article:11056374 | pubmed:author | pubmed-author:SinghA KAK | lld:pubmed |
| pubmed-article:11056374 | pubmed:author | pubmed-author:GoelH CHC | lld:pubmed |
| pubmed-article:11056374 | pubmed:author | pubmed-author:BabbarA KAK | lld:pubmed |
| pubmed-article:11056374 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11056374 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:11056374 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11056374 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11056374 | pubmed:pagination | 587-92 | lld:pubmed |
| pubmed-article:11056374 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:11056374 | pubmed:meshHeading | pubmed-meshheading:11056374... | lld:pubmed |
| pubmed-article:11056374 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11056374 | pubmed:articleTitle | Evaluation of (99m)Tc-labeled photosan-3, a hematoporphyrin derivative, as a potential radiopharmaceutical for tumor scintigraphy. | lld:pubmed |
| pubmed-article:11056374 | pubmed:affiliation | Department of Radiopharmaceuticals, Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi, India. | lld:pubmed |
| pubmed-article:11056374 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11056374 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11056374 | lld:pubmed |
