| pubmed-article:11054668 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0282549 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0069141 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C1334894 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C1704851 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11054668 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:11054668 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11054668 | pubmed:dateCreated | 2000-11-13 | lld:pubmed |
| pubmed-article:11054668 | pubmed:abstractText | Stable clones of HL-60 cells in which nucleophosmin/B23 was over-expressed were established. Less percentages (4-20%) of nucleophosmin/B23 over-expressed (pCR3-B23) cells exhibited the morphological characteristic of apoptosis as compared with control vector-transfected (pCR3) cells (6-53%) during the 10 microM RA treatment for 1-4 days. In flow cytometry analysis, a block in the G1 phase was noted in all the pCR3-B23 and pCR3 cells after 2 days of 10 microM RA treatment and continued to be observed at all times measured up to 6 days. Smaller peaks of apoptotic cells with less than G1 DNA content were observed in pCR3-B23 as compared with pCR3 cells after 4-6 days of 10 microM RA treatment. As measured by expressions of differentiation markers and the functional assessment of the ability to reduce nitroblue-tetrazolium, our results further showed that over-expression of nucleophosmin/B23 decreased the response of the cells to RA-induced differentiation. Less cleavage of PARP and in vitro caspase-3 activity were observed in PCR3-B23 cells as compared with pCR3 cells treated with 10 microM RA for 3-4 days. IRF-1 was induced after 6 hr of 10 microM RA treatment in the pCR3-B23 and pCR3 cells. Significantly more nucleophosmin/B23 was co-immunoprecipitated with IRF-1 from pCR3-B23 cells than from pCR3 cells during RA treatment (10 microM; 24 hr, 96 hr). The IRF-1 transcriptional activity was found to be attenuated in pCR3-B23 cells as compared with pCR3 cells during the treatment of cells with RA. Nucleophosmin/B23, through interacting with IRF-1, plays an important role in the control of the susceptibility of cells to RA-induced differentiation and apoptosis. | lld:pubmed |
| pubmed-article:11054668 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11054668 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054668 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11054668 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11054668 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:11054668 | pubmed:author | pubmed-author:HsuC YCY | lld:pubmed |
| pubmed-article:11054668 | pubmed:author | pubmed-author:YungB YBY | lld:pubmed |
| pubmed-article:11054668 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11054668 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11054668 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:11054668 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11054668 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11054668 | pubmed:pagination | 392-400 | lld:pubmed |
| pubmed-article:11054668 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
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| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
| pubmed-article:11054668 | pubmed:meshHeading | pubmed-meshheading:11054668... | lld:pubmed |
| pubmed-article:11054668 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11054668 | pubmed:articleTitle | Over-expression of nucleophosmin/B23 decreases the susceptibility of human leukemia HL-60 cells to retinoic acid-induced differentiation and apoptosis. | lld:pubmed |
| pubmed-article:11054668 | pubmed:affiliation | Graduate Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China. | lld:pubmed |
| pubmed-article:11054668 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11054668 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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