| pubmed-article:11054259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0242918 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0014499 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0439234 | lld:lifeskim |
| pubmed-article:11054259 | lifeskim:mentions | umls-concept:C0036152 | lld:lifeskim |
| pubmed-article:11054259 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:11054259 | pubmed:dateCreated | 2000-11-28 | lld:pubmed |
| pubmed-article:11054259 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:abstractText | HIV-1 envelope sequence variants were RT-PCR amplified from serum samples cryopreserved in San Francisco in 1978-1979. The HIV-1 subtype B env V3-V5 sequences from four homosexual men clustered phylogenetically, with a median nucleotide distance of 2.8%, reflecting a recent common origin. These early U.S. HIV-1 env variants mapped close to the phylogenetic root of the subtype B tree while env variants collected in the United States throughout the 1980s and 1990s showed, on average, increasing genetic diversity and divergence from the subtype B consensus sequence. These results indicate that the majority of HIV-1 currently circulating in the United States may be descended from an initial introduction and rapid spread during the mid- to late 1970s of subtype B viruses with limited variability (i.e., a founder effect). As expected from the starburst-shaped phylogeny of HIV-1 subtype B, contemporary U.S. strains were, on average, more closely related at the nucleic acid and amino acid levels to the earlier 1978-1979 env variants than to each other. The growing levels of HIV-1 genetic diversity, one of multiple obstacles in designing a protective vaccine, may therefore be mitigated by using epidemic founding variants as antigenic strains for protection against contemporary strains. | lld:pubmed |
| pubmed-article:11054259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11054259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11054259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11054259 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11054259 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:11054259 | pubmed:author | pubmed-author:FoleyBB | lld:pubmed |
| pubmed-article:11054259 | pubmed:author | pubmed-author:PapJJ | lld:pubmed |
| pubmed-article:11054259 | pubmed:author | pubmed-author:BuchbinderSS | lld:pubmed |
| pubmed-article:11054259 | pubmed:author | pubmed-author:DelwartE LEL | lld:pubmed |
| pubmed-article:11054259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11054259 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11054259 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11054259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11054259 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11054259 | pubmed:pagination | 1463-9 | lld:pubmed |
| pubmed-article:11054259 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:meshHeading | pubmed-meshheading:11054259... | lld:pubmed |
| pubmed-article:11054259 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11054259 | pubmed:articleTitle | Apparent founder effect during the early years of the San Francisco HIV type 1 epidemic (1978-1979). | lld:pubmed |
| pubmed-article:11054259 | pubmed:affiliation | Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87501, USA. | lld:pubmed |
| pubmed-article:11054259 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11054259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11054259 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11054259 | lld:pubmed |
