| pubmed-article:11050241 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11050241 | lifeskim:mentions | umls-concept:C0332621 | lld:lifeskim |
| pubmed-article:11050241 | lifeskim:mentions | umls-concept:C0020222 | lld:lifeskim |
| pubmed-article:11050241 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:11050241 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11050241 | pubmed:dateCreated | 2000-11-28 | lld:pubmed |
| pubmed-article:11050241 | pubmed:abstractText | Self-organization has been demonstrated in a variety of systems ranging from chemical-molecular to ecosystem levels, and evidence is accumulating that it is also fundamental for animal development. Yet, self-organization can be approached experimentally in only a few animal systems. Cells isolated from the simple metazoan Hydra can aggregate and form a complete animal by self-organization. By using this experimental system, we found that clusters of 5-15 epithelial cells are necessary and sufficient to form de novo head-organizing centers in an aggregate. Such organizers presumably arise by a community effect from a small number of cells that express the conserved HyBra1 and HyWnt genes. These local sources then act to pattern and instruct the surrounding cells as well as generate a field of lateral inhibition that ranges up to 1,000 microm. We propose that conserved patterning systems in higher animals originate from extremely robust and flexible molecular self-organizing systems that were selected for during early metazoan evolution. | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11050241 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050241 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11050241 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11050241 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11050241 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:LuftSS | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:BodeH RHR | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:HolsteinT WTW | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:TechnauUU | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:HobmayerBB | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:RentzschFF | lld:pubmed |
| pubmed-article:11050241 | pubmed:author | pubmed-author:Cramer von... | lld:pubmed |
| pubmed-article:11050241 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11050241 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:11050241 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11050241 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11050241 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11050241 | pubmed:pagination | 12127-31 | lld:pubmed |
| pubmed-article:11050241 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11050241 | pubmed:meshHeading | pubmed-meshheading:11050241... | lld:pubmed |
| pubmed-article:11050241 | pubmed:meshHeading | pubmed-meshheading:11050241... | lld:pubmed |
| pubmed-article:11050241 | pubmed:meshHeading | pubmed-meshheading:11050241... | lld:pubmed |
| pubmed-article:11050241 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11050241 | pubmed:articleTitle | Parameters of self-organization in Hydra aggregates. | lld:pubmed |
| pubmed-article:11050241 | pubmed:affiliation | Department of Molecular Cell Biology, Darmstadt University of Technology, Schnittspahnstr. 10, 64287 Darmstadt, Germany. technau@bio.tu-darmstadt.de | lld:pubmed |
| pubmed-article:11050241 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11050241 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11050241 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11050241 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11050241 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11050241 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11050241 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11050241 | lld:pubmed |
