| pubmed-article:1104659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C0025266 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C0039601 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C2247136 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1104659 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1104659 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1104659 | pubmed:dateCreated | 1976-3-1 | lld:pubmed |
| pubmed-article:1104659 | pubmed:abstractText | A variety of studies in man and animals demonstrate that testosterone (T) is aromatized to estradiol (E) in the hypothalamus and limbic system. These observations suggested the possibility that conversion to E is an absolute requirement for the biologic activity of T on the hypothalamic-pituitary axis. Since this hypothesis implies a common mechanism of action of these two steroids, the demonstration of divergent effects of T and E on luteinizing hormone (LH) secretion would exclude this possibility. To test this hypothesis, the actions of T and E on three separate aspects of LH release (mean LH, pulsatile LH secretion, and responsiveness to LH-releasing hormone [LH-RH]) were contrasted. T and E, infused at two times their respective production rates into normal men, reduced mean LH levels similarly during 6 h of steroid infusion and for 6 h thereafter. However, these steroids exerted different effects on pulsatile secretion. E reduced the amplitude of spontaneous LH pulse from pre- and postinfusion control levels of 75+/-14 and 68+/-5.6% (SEM) to 39+/-5.7%. In contrast, T increased pulse amplited to 96+/-14% and decreased pulse frequency from basal levels of 3.4+/-0.31 to 1.8+/-0.31 pulses/6h. The site of suppressive action was determined by administering 25 microgms of LH-RH to the same men during T and E infusions and during three additional control periods without steroid administration. LH-RH produced similar 170-190% increments in serum LH during the three control periods and during T infusion. In contrast, E markedly blunted (76+/-31%, p less than 0.005) the LH response to LH-RH. Under the conditions of acute steroid infusion at doses (utilized in these experiments) producing similar inhibition of mean LH, E but not T acted directly on the pituitary to diminish LH-RH responsiveness. As further support that androgens can act without conversion to estrogens, the effects of a nonaromatizable androgen, dihydrotestosterone (DHT), on mean LH levels were studied. DHT, infused at the same rate as T, suppressed mean LH to a similar but somewhat greater extent than T. Since T and E produced divergent effects on LH secretion and a nonaromatizable androgen, DHT, suppressed mean LH, aromatization is not a necessary prerequisite for the action of androgens on the hypothalamic-pituitary axis. | lld:pubmed |
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| pubmed-article:1104659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1104659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1104659 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1104659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1104659 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1104659 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1104659 | pubmed:author | pubmed-author:SantenR JRJ | lld:pubmed |
| pubmed-article:1104659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1104659 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:1104659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1104659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1104659 | pubmed:pagination | 1555-63 | lld:pubmed |
| pubmed-article:1104659 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1104659 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1104659 | pubmed:articleTitle | Is aromatization of testosterone to estradiol required for inhibition of luteinizing hormone secretion in men? | lld:pubmed |
| pubmed-article:1104659 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1104659 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1104659 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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