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pubmed-article:11045430pubmed:abstractTextDespite of recent improvements in the treatment of many malignant diseases, pancreatic ductal adenocarcinoma is still a disease with an extremely poor prognosis with current modes of treatment. Gene therapy has been suggested as a novel approach also against pancreatic cancer. Previous studies have been carried out predominantly with immunodeficient animal models and with tumors growing in environments other than the pancreas. We have attempted to mimic a more clinically relevant situation and investigated suicide gene therapy strategy for experimental pancreatic cancer in animals with an intact immune system.lld:pubmed
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pubmed-article:11045430pubmed:articleTitleEvaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.lld:pubmed
pubmed-article:11045430pubmed:affiliationDepartment of Surgery, Kuopio University Hospital, Finland. kimmo.makinen@kuh.filld:pubmed
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