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pubmed-article:11043777pubmed:abstractTextFollicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.lld:pubmed
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pubmed-article:11043777pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:11043777pubmed:articleTitleFollicular stromal cells and lymphocyte homing to follicles.lld:pubmed
pubmed-article:11043777pubmed:affiliationDepartment of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA. cyster@itsa.ucsf.edulld:pubmed
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