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pubmed-article:11040188pubmed:abstractTextAbnormal presentation of luminal constituents to the mucosal immune system, caused by dysfunction of the intestinal epithelial barrier, is a candidate theory for the cause of Crohn's disease. Increased epithelial permeability is found in subgroups of patients at high risk for the development of Crohn's disease and has been found to precede disease recurrence. Clinical observations have suggested that disease recurrence can follow times of increased psychological stress, although the underlying mechanism remains obscure. We hypothesized that environmental stress increases gastrointestinal permeability.lld:pubmed
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pubmed-article:11040188pubmed:articleTitleEnvironmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat.lld:pubmed
pubmed-article:11040188pubmed:affiliationGastrointestinal Research Group, University of Calgary, Alberta, Canada. meddings@ucalgary.calld:pubmed
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