| pubmed-article:11038529 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0332437 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0042765 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0035150 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0887847 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0521033 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:11038529 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11038529 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:11038529 | pubmed:dateCreated | 2007-3-23 | lld:pubmed |
| pubmed-article:11038529 | pubmed:abstractText | Reduced accumulation of the GTP-binding protein G(i)alpha subunit CPG-1, due either to hypovirus infection or transgenic cosuppression, correlates with virulence attenuation of the chestnut blight fungus, Cryphonectria parasitica. The role of G protein-mediated signal transduction in fungal virulence was further examined by targeted disruption of the gene cpg-1, encoding CPG-1, and a second Galpha gene, cpg-2, encoding the subunit CPG-2. Disruption of cpg-1 resulted in a set of phenotypic changes similar to, but more severe than, those associated with hypovirus infection. Changes included a marked reduction in fungal growth rate and loss of virulence, asexual sporulation, female fertility, and transcriptional induction of the gene lac-1, encoding the enzyme laccase. In contrast, cpg-2 disruption resulted in only slight reductions in growth rate and asexual sporulation and no significant reduction in virulence, female fertility, or lac-1 mRNA inducibility. These results provide definitive confirmation of previous correlative evidence that suggested a requirement of CPG-1-linked signaling for a number of fungal processes, including virulence and reproduction, while demonstrating that a second Galpha, CPG-2, is dispensable for these processes. They also significantly strengthen support for the apparent linkage between hypovirus-mediated disruption of G protein signal transduction and attenuation of fungal virulence. | lld:pubmed |
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| pubmed-article:11038529 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11038529 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038529 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:11038529 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11038529 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11038529 | pubmed:author | pubmed-author:NussD LDL | lld:pubmed |
| pubmed-article:11038529 | pubmed:author | pubmed-author:GanRR | lld:pubmed |
| pubmed-article:11038529 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11038529 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:11038529 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:11038529 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11038529 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11038529 | pubmed:pagination | 14122-7 | lld:pubmed |
| pubmed-article:11038529 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
| pubmed-article:11038529 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:11038529 | pubmed:articleTitle | Distinct roles for two G protein alpha subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption. | lld:pubmed |
| pubmed-article:11038529 | pubmed:affiliation | Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, University of Maryland, College Park, MD 20742-3351, USA. | lld:pubmed |
| pubmed-article:11038529 | pubmed:publicationType | Journal Article | lld:pubmed |
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