| pubmed-article:11038400 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0038999 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0241938 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:11038400 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:11038400 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11038400 | pubmed:dateCreated | 2000-11-16 | lld:pubmed |
| pubmed-article:11038400 | pubmed:abstractText | The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conventional whole-cell patch clamp technique. The degree of cell swelling as a result of hypotonic challenge was monitored using a video image analysis system. The changes in intracellular Ca2+ concentration ([Ca2+]i) were measured by microfluorimetry. The pharmacological and voltage activation profile suggests a typical dihydropyridine-sensitive L-type Ca2+ current. Cell swelling, induced by hypotonic challenge, enhanced the amplitude of currents through L-type Ca2+ channels without significant effects on steady-state voltage dependency. After treatment with the L-type Ca2+ channel agonist Bay K 8644 (0.1-2 microM), no further significant increase in calcium channel current or corresponding [Ca2+]i transients were provoked by the swelling. The above results demonstrated that the presence of L-type Ca2+ current in smooth muscle cells of the human stomach and the augmentation of the current are closely associated with the volume increase resulting from hypotonic swelling. | lld:pubmed |
| pubmed-article:11038400 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11038400 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11038400 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11038400 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11038400 | pubmed:issn | 0958-0670 | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:LeeH YHY | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:KimY IYI | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:ParkM KMK | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:KimC HCH | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:ReedG BGB | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:UhmD YDY | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:SoII | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:RheeP LPL | lld:pubmed |
| pubmed-article:11038400 | pubmed:author | pubmed-author:KempG LGL | lld:pubmed |
| pubmed-article:11038400 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11038400 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:11038400 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11038400 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11038400 | pubmed:pagination | 497-504 | lld:pubmed |
| pubmed-article:11038400 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11038400 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11038400 | pubmed:articleTitle | Hypotonic swelling increases L-type calcium current in smooth muscle cells of the human stomach. | lld:pubmed |
| pubmed-article:11038400 | pubmed:affiliation | Department of Physiology, Medicine and Surgery, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea. | lld:pubmed |
| pubmed-article:11038400 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11038400 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11038400 | lld:pubmed |
