| pubmed-article:11034314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C1335872 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C1426207 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C1426212 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:11034314 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11034314 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:11034314 | pubmed:dateCreated | 2000-11-7 | lld:pubmed |
| pubmed-article:11034314 | pubmed:abstractText | Interleukin-10 (IL-10) has been used in the treatment of viral hepatitis in interferon-alpha (IFN-alpha) non-responders while patients who have high levels of IL-10 are poorly responsive to IFN-alpha. The mechanism underlying such controversial functions of IL-10 remains unknown. Here we demonstrated that injection of IL-10 into mice attenuated IFN-alpha-induced signal transducer and activator transcription factor (STAT)1 tyrosine phosphorylation in the liver. Reverse transcriptase-polymerase chain reaction assay demonstrated that mouse liver expressed high levels of IL-10 receptor 2 (IL-10R2) but low levels of IL-10R1. Injection of IL-10 into mice activated STAT3 but not STAT1 tyrosine phosphorylation and induced suppressor of cytokine signal 2 (SOCS2), SOCS3, and cytokine-inducible SH2 protein (CIS) mRNA expression in the liver. Furthermore, overexpression of SOCS2 or SOCS3 inhibited IFN-alpha-induced reporter activity in hepatic cells. These findings suggest that IL-10 inhibits IFN-alpha-activated STAT1 in the liver, at least in part, by inducing SOCS2, SOCS3, and CIS expression, which may be responsible for the resistance of IFN-alpha therapy in patients who have high levels of IL-10 and recommends that IL-10 treatment for viral hepatitis should be cautious. | lld:pubmed |
| pubmed-article:11034314 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11034314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11034314 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11034314 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11034314 | pubmed:author | pubmed-author:GayHH | lld:pubmed |
| pubmed-article:11034314 | pubmed:author | pubmed-author:SheaWW | lld:pubmed |
| pubmed-article:11034314 | pubmed:author | pubmed-author:HongFF | lld:pubmed |
| pubmed-article:11034314 | pubmed:author | pubmed-author:NguyenV AVA | lld:pubmed |
| pubmed-article:11034314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11034314 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11034314 | pubmed:volume | 480 | lld:pubmed |
| pubmed-article:11034314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11034314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11034314 | pubmed:pagination | 132-6 | lld:pubmed |
| pubmed-article:11034314 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11034314 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11034314 | pubmed:articleTitle | IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. | lld:pubmed |
| pubmed-article:11034314 | pubmed:affiliation | Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA. | lld:pubmed |
| pubmed-article:11034314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11034314 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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