| pubmed-article:11034305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C0043316 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C1335186 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11034305 | lifeskim:mentions | umls-concept:C0910920 | lld:lifeskim |
| pubmed-article:11034305 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:11034305 | pubmed:dateCreated | 2000-11-7 | lld:pubmed |
| pubmed-article:11034305 | pubmed:abstractText | To study the regulation of the human xanthine oxidoreductase (XOR) gene, we cloned 1.9 kb of the promoter region. In reporter gene assays, a construct encompassing nucleotides between 142 to +42 conferred maximal basal activity of the XOR promoter in 293T cells, in comparison with shorter (-92 to +42) or longer (up to -1937 to +42) constructs. The promoter activity was low in NIH-3T3 cells. The most active construct contained a putative CCAAT motif at -119 to -123. Electrophoretic mobility shift assays showed that this sequence binds the ubiquitous nuclear factor Y (NF-Y). Mutation of the CCAAT motif (CTGAT) abolished the NF-Y binding and considerably reduced the promoter activity. Our data suggest an important functional role for NF-Y in the transcriptional activation of the human XOR gene. | lld:pubmed |
| pubmed-article:11034305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11034305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11034305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11034305 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11034305 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11034305 | pubmed:author | pubmed-author:RaivioK OKO | lld:pubmed |
| pubmed-article:11034305 | pubmed:author | pubmed-author:PalvimoJ JJJ | lld:pubmed |
| pubmed-article:11034305 | pubmed:author | pubmed-author:LapattoRR | lld:pubmed |
| pubmed-article:11034305 | pubmed:author | pubmed-author:MartelinEE | lld:pubmed |
| pubmed-article:11034305 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11034305 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11034305 | pubmed:volume | 480 | lld:pubmed |
| pubmed-article:11034305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11034305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11034305 | pubmed:pagination | 84-8 | lld:pubmed |
| pubmed-article:11034305 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
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| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
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| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
| pubmed-article:11034305 | pubmed:meshHeading | pubmed-meshheading:11034305... | lld:pubmed |
| pubmed-article:11034305 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11034305 | pubmed:articleTitle | Nuclear factor Y activates the human xanthine oxidoreductase gene promoter. | lld:pubmed |
| pubmed-article:11034305 | pubmed:affiliation | Hospital for Children and Adolescents, Research Laboratory, University of Helsinki, Finland. eeva.martelin@hus.fi | lld:pubmed |
| pubmed-article:11034305 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11034305 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7498 | entrezgene:pubmed | pubmed-article:11034305 | lld:entrezgene |
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