| pubmed-article:11032854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0029432 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0162745 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0333562 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:11032854 | lifeskim:mentions | umls-concept:C0442802 | lld:lifeskim |
| pubmed-article:11032854 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11032854 | pubmed:dateCreated | 2000-11-15 | lld:pubmed |
| pubmed-article:11032854 | pubmed:abstractText | Mice carrying a targeted mutation (r) in Col1a1, encoding a collagenase-resistant form of type I collagen, have altered skeletal remodeling. In hematoxylin and eosin-stained paraffin sections, we detect empty lacunae in osteocytes in calvariae from Col1a1(r/r) mice at age 2 weeks, increasing through age 10-12 months. Empty lacunae appear to result from osteocyte apoptosis, since staining of osteocytes/periosteal osteoblasts with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling is increased in Col1a1(r/r) relative to wild-type bones. Osteocyte perilacunar matrices stained with Ab that recognizes collagenase collagen alpha1(I) chain cleavage ends in wild-type but not Col1a1(r/r) calvariae. Increased calvarial periosteal and tibial/femoral endosteal bone deposition was found in Col1a1(r/r) mice from ages 3-12 months. Calcein labeling of calvarial surfaces was increased in Col1a1(r/r) relative to wild-type mice. Daily injections of synthetic parathyroid hormone for 30 days increased calcein-surface labeling in wild-type but caused no further increase in the already high calcein staining of Col1a1(r/r) bones. Thus, failure of collagenase cleavage of type I collagen in Col1a1(r/r) mice is associated with osteocyte/osteoblast death but increases bone deposition in a manner that mimics the parathyroid hormone-induced bone surface activation seen in wild-type mice. | lld:pubmed |
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| pubmed-article:11032854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11032854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11032854 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11032854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11032854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11032854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11032854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11032854 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11032854 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11032854 | pubmed:author | pubmed-author:WangYY | lld:pubmed |
| pubmed-article:11032854 | pubmed:author | pubmed-author:KraneS MSM | lld:pubmed |
| pubmed-article:11032854 | pubmed:author | pubmed-author:ZhakSS | lld:pubmed |
| pubmed-article:11032854 | pubmed:author | pubmed-author:ByrneM HMH | lld:pubmed |
| pubmed-article:11032854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11032854 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:11032854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11032854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11032854 | pubmed:pagination | 941-9 | lld:pubmed |
| pubmed-article:11032854 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11032854 | pubmed:meshHeading | pubmed-meshheading:11032854... | lld:pubmed |
| pubmed-article:11032854 | pubmed:meshHeading | pubmed-meshheading:11032854... | lld:pubmed |
| pubmed-article:11032854 | pubmed:meshHeading | pubmed-meshheading:11032854... | lld:pubmed |
| pubmed-article:11032854 | pubmed:meshHeading | pubmed-meshheading:11032854... | lld:pubmed |
| pubmed-article:11032854 | pubmed:meshHeading | pubmed-meshheading:11032854... | lld:pubmed |
