Linked Life Data

11031083

Source:http://linkedlifedata.com/resource/pubmed/id/11031083

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pubmed-article:11031083pubmed:abstractTextThe inflammatory response that ensues during the initial 48 to 72 h after spinal cord injury causes considerable secondary damage to neurons and glia. Infiltration of proinflammatory-activated neutrophils and monocytes/macrophages into the cord contributes to spinal cord injury-associated secondary damage. beta2 integrins play an essential role in leukocyte trafficking and activation and arbitrate cell-cell interactions during inflammation. The beta2 integrin, alphaDbeta2, is expressed on monocytes/macrophages and neutrophils and binds to vascular adhesion molecule-1 (VCAM-1). The increased expression of VCAM-1 during central nervous system (CNS) inflammation likely contributes to leukocyte extravasation into the CNS. Accordingly, blocking the interaction between alphaDbeta2 and VCAM-1 may attenuate the inflammatory response at the SCI site. We investigated whether the administration of monoclonal antibodies (mAbs) specific for the rat alphaD subunit would reduce the inflammatory response after a spinal cord transection injury in rats. At a 1 mg/kg dose two of three anti-alphaD mAbs caused a significant ( approximately 65%) reduction in the number of macrophages at the injury site and one anti-alphaD mAb led to a approximately 43% reduction in the number of neutrophils at the SCI site. Thus, our results support the concept that the alphaDbeta2 integrins play an important role in the trafficking of leukocytes to a site of central nervous system inflammation. This study also offers preliminary evidence that anti-alphaD mAbs can reduce the extravasation of macrophages and, to a lesser extent, neutrophils, to the SCI site.lld:pubmed
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pubmed-article:11031083pubmed:authorpubmed-author:WeaverL CLClld:pubmed
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pubmed-article:11031083pubmed:copyrightInfoCopyright 2000 Academic Press.lld:pubmed
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pubmed-article:11031083pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11031083pubmed:articleTitleInhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment.lld:pubmed
pubmed-article:11031083pubmed:affiliationThe Neurodegeneration Research Group, The John P. Robarts Research Institute, London, Ontario, N6A 5K8, Canada.lld:pubmed
pubmed-article:11031083pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11031083pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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