| pubmed-article:11030756 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11030756 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:11030756 | lifeskim:mentions | umls-concept:C0497406 | lld:lifeskim |
| pubmed-article:11030756 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:11030756 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:11030756 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:11030756 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:11030756 | pubmed:dateCreated | 2000-11-3 | lld:pubmed |
| pubmed-article:11030756 | pubmed:abstractText | The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule. IRS-2 inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance and reduced beta cell mass. We tested the hypothesis that a common non-conservative amino acid substitution of IRS-2 (G1057D) might interact with overweight in the pathogenesis of type 2 diabetes. The variant was genotyped in 193 Italian patients with type 2 diabetes and 206 control subjects. In the absence of overweight, the risk of type 2 diabetes decreased according to the dosage of the D1057 allele (odds ratio for GD genotype 0.46 [95% CI 0.25-0.86]; DD genotype 0.18 [0.04-0.68]; P for trend = 0.0012). Conversely, the interaction between overweight and genotype increased the risk of type 2 diabetes according to the dosage of the D1057 allele (odds ratio for GD genotype 2.50 [1.11-5.65]; DD genotype 5.74 [1.11-29. 78]; P for trend = 0.0047). Among controls, fasting C-peptide levels, after adjustment for plasma glucose, were inversely related to the dosage of the D1057 allele (P = 0.020). This finding suggested that carriers of the D1057 allele may have higher insulin sensitivity and supported the protective effect of this allele. Conversely, among overweight patients there was a parallel increase in fasting plasma glucose (P for trend = 0.037) and fasting C-peptide according to the dosage of the D1057 allele, suggesting that higher insulin resistance and relative beta cell failure contributed to the increased risk of type 2 diabetes in overweight carriers of this allele. These data provide evidence for a strong association between type 2 diabetes and the G1057D common genetic variant of IRS-2, which appears to be protective against type 2 diabetes in a codominant fashion. Overweight appears to modify the effect of this polymorphism toward a higher risk of type 2 diabetes. Carriers of this polymorphism may represent an elective target for prevention of type 2 diabetes through preventing or treating excessive weight. | lld:pubmed |
| pubmed-article:11030756 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11030756 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11030756 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11030756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11030756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11030756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11030756 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11030756 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11030756 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:VolpeGG | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:RomanoFF | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:BattistaPP | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:CamaAA | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:CapaniFF | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:Della... | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:Mariani-Costa... | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:MammarellaSS | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:PalmirottaRR | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:EspositoD LDL | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:VitulloPP | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:CreatiBB | lld:pubmed |
| pubmed-article:11030756 | pubmed:author | pubmed-author:Di ValerioAA | lld:pubmed |
| pubmed-article:11030756 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11030756 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:11030756 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11030756 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11030756 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11030756 | pubmed:pagination | 2517-21 | lld:pubmed |
| pubmed-article:11030756 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11030756 | pubmed:meshHeading | pubmed-meshheading:11030756... | lld:pubmed |
| pubmed-article:11030756 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11030756 | pubmed:articleTitle | Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. | lld:pubmed |
| pubmed-article:11030756 | pubmed:affiliation | Department of Oncology and Neurosciences, Section of Molecular Pathology, University Gabriele D'Annunzio, Chieti, Italy. | lld:pubmed |
| pubmed-article:11030756 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11030756 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:8660 | entrezgene:pubmed | pubmed-article:11030756 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11030756 | lld:pubmed |
