| pubmed-article:11024555 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11024555 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11024555 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:11024555 | lifeskim:mentions | umls-concept:C0014063 | lld:lifeskim |
| pubmed-article:11024555 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:11024555 | lifeskim:mentions | umls-concept:C0332261 | lld:lifeskim |
| pubmed-article:11024555 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11024555 | pubmed:dateCreated | 2000-11-3 | lld:pubmed |
| pubmed-article:11024555 | pubmed:abstractText | A case with stable multiple sclerosis (MS) and T cell responses which initially focused on peptide 16-38 of myelin basic protein (MBP) allowed us to investigate the dynamics of the MBP-specific T cell repertoire and its relationship with disease progression. Epitope mapping experiments and T cell receptor usage of MBP-reactive T cell lines (obtained at four distinct time points over a 7-year period) showed a spreading of the response. Transient expansions and persistence of T cells recognizing different MBP epitopes were also detected. The patient's expanded disability status scale and magnetic resonance imaging lesion load remained stable. Our case shows both persistent self-recognitions and determinant spreading in stable MS. This finding suggests that the relationship between dynamics of self-recognition and disease progression is highly complex. | lld:pubmed |
| pubmed-article:11024555 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11024555 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024555 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11024555 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024555 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024555 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11024555 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11024555 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:GasperiniCC | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:PernaAA | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:RistoriGG | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:UccelliAA | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:SalvettiMM | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:ButtinelliCC | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:GiubileiFF | lld:pubmed |
| pubmed-article:11024555 | pubmed:author | pubmed-author:GiuntiDD | lld:pubmed |
| pubmed-article:11024555 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11024555 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:11024555 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:11024555 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11024555 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11024555 | pubmed:pagination | 240-3 | lld:pubmed |
| pubmed-article:11024555 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:meshHeading | pubmed-meshheading:11024555... | lld:pubmed |
| pubmed-article:11024555 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11024555 | pubmed:articleTitle | Myelin basic protein intramolecular spreading without disease progression in a patient with multiple sclerosis. | lld:pubmed |
| pubmed-article:11024555 | pubmed:affiliation | Dipartimento di Scienze Neurologiche, Università 'La Sapienza', Rome, Italy. | lld:pubmed |
| pubmed-article:11024555 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11024555 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:11024555 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
