| pubmed-article:11024153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C0006413 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:11024153 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:11024153 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11024153 | pubmed:dateCreated | 2000-11-20 | lld:pubmed |
| pubmed-article:11024153 | pubmed:abstractText | The tumorigenic potential of the Burkitt lymphoma (BL) cell line Akata is dependent on the restricted latency program of Epstein-Barr virus (EBV) that is characteristically maintained in BL tumors. Within these cells, EBV-mediated inhibition of apoptosis correlates with an up-regulation of BCL-2 levels in concert with a down-regulation in c-MYC expression that occurs under growth-limiting conditions. Here we addressed whether EBV's effects on apoptosis and tumorigenicity are mediated by the EBV small RNAs EBER-1 and EBER-2. Stable expression of the EBERs in EBV-negative Akata BL cells, at levels comparable to those in EBV-positive cells, significantly enhanced the tumorigenic potential of EBV-negative BL cells in SCID mice, but did not fully restore tumorigenicity relative to EBV-positive Akata cells. Furthermore, wild-type or greater levels of EBER expression in EBV-negative Akata cells did not promote BL cell survival. These data therefore suggest that EBV can contribute to BL through at least two avenues: an EBER-dependent mechanism that enhances tumorigenic potential independent of a direct effect on apoptosis, and a second mechanism, mediated by an as-yet-unidentified EBV gene(s), that offsets the proapoptotic consequences of deregulated c-MYC in BL. | lld:pubmed |
| pubmed-article:11024153 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11024153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11024153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11024153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11024153 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11024153 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11024153 | pubmed:author | pubmed-author:YangCC | lld:pubmed |
| pubmed-article:11024153 | pubmed:author | pubmed-author:ClevelandJ... | lld:pubmed |
| pubmed-article:11024153 | pubmed:author | pubmed-author:SampleJ TJT | lld:pubmed |
| pubmed-article:11024153 | pubmed:author | pubmed-author:SunH SHS | lld:pubmed |
| pubmed-article:11024153 | pubmed:author | pubmed-author:RhyneP WPW | lld:pubmed |
| pubmed-article:11024153 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11024153 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:11024153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11024153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11024153 | pubmed:pagination | 10223-8 | lld:pubmed |
| pubmed-article:11024153 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11024153 | pubmed:meshHeading | pubmed-meshheading:11024153... | lld:pubmed |
| pubmed-article:11024153 | pubmed:meshHeading | pubmed-meshheading:11024153... | lld:pubmed |
| pubmed-article:11024153 | pubmed:meshHeading | pubmed-meshheading:11024153... | lld:pubmed |
| pubmed-article:11024153 | pubmed:meshHeading | pubmed-meshheading:11024153... | lld:pubmed |
| pubmed-article:11024153 | pubmed:meshHeading | pubmed-meshheading:11024153... | lld:pubmed |
