| pubmed-article:11021803 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C1412727 | lld:lifeskim |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C1454853 | lld:lifeskim |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C1514524 | lld:lifeskim |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:11021803 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11021803 | pubmed:issue | 5489 | lld:pubmed |
| pubmed-article:11021803 | pubmed:dateCreated | 2000-10-11 | lld:pubmed |
| pubmed-article:11021803 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11021803 | pubmed:abstractText | Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity. | lld:pubmed |
| pubmed-article:11021803 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11021803 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11021803 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11021803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11021803 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11021803 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11021803 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:TangJJ | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:GhoshA KAK | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:WuSS | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:LieAA | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:HoodPP | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:KoelschGG | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:ZhangX CXC | lld:pubmed |
| pubmed-article:11021803 | pubmed:author | pubmed-author:TerzyanSS | lld:pubmed |
| pubmed-article:11021803 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11021803 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11021803 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:11021803 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11021803 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11021803 | pubmed:pagination | 150-3 | lld:pubmed |
| pubmed-article:11021803 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11021803 | pubmed:meshHeading | pubmed-meshheading:11021803... | lld:pubmed |
| pubmed-article:11021803 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11021803 | pubmed:articleTitle | Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. | lld:pubmed |
| pubmed-article:11021803 | pubmed:affiliation | Protein Studies Program and Crystallography Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. | lld:pubmed |
| pubmed-article:11021803 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11021803 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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