| pubmed-article:11015230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0058836 | lld:lifeskim |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0441587 | lld:lifeskim |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11015230 | lifeskim:mentions | umls-concept:C0031610 | lld:lifeskim |
| pubmed-article:11015230 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:11015230 | pubmed:dateCreated | 2000-11-1 | lld:pubmed |
| pubmed-article:11015230 | pubmed:abstractText | Dynamin is a large GTPase involved in the regulation of membrane constriction and fission during receptor-mediated endocytosis. Dynamin contains a pleckstrin-homology domain which is essential for endocytosis and which binds to anionic phospholipids. Here, we show for the first time that dynamin is a membrane-active molecule capable of penetrating into the acyl chain region of membrane lipids. Lipid penetration is strongly stimulated by phosphatidic acid (PA), phosphatidylinositol 4-phosphate, and phosphatidylinositol 4, 5-bisphosphate. Though binding is more efficient in the presence of the phosphoinositides, a much larger part of the dynamin molecule penetrates into PA-containing mixed-lipid systems. Thus, local lipid metabolism will dramatically influence dynamin-lipid interactions, and dynamin-lipid interactions are likely to play an important role in dynamin-dependent endocytosis. Our data suggest that dynamin is directly involved in membrane destabilization, a prerequisite to membrane fission. | lld:pubmed |
| pubmed-article:11015230 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11015230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11015230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11015230 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11015230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11015230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11015230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11015230 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11015230 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:11015230 | pubmed:author | pubmed-author:de KruijffBB | lld:pubmed |
| pubmed-article:11015230 | pubmed:author | pubmed-author:DemelR ARA | lld:pubmed |
| pubmed-article:11015230 | pubmed:author | pubmed-author:SchmidS LSL | lld:pubmed |
| pubmed-article:11015230 | pubmed:author | pubmed-author:BurgerK NKN | lld:pubmed |
| pubmed-article:11015230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11015230 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11015230 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:11015230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11015230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11015230 | pubmed:pagination | 12485-93 | lld:pubmed |
| pubmed-article:11015230 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11015230 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11015230 | pubmed:articleTitle | Dynamin is membrane-active: lipid insertion is induced by phosphoinositides and phosphatidic acid. | lld:pubmed |
| pubmed-article:11015230 | pubmed:affiliation | Department of Biochemistry of Membranes, Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. K.N.J.Burger@bio.uu.nl | lld:pubmed |
| pubmed-article:11015230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11015230 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11015230 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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