| pubmed-article:11003165 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11003165 | lifeskim:mentions | umls-concept:C2916841 | lld:lifeskim |
| pubmed-article:11003165 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:11003165 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11003165 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11003165 | pubmed:dateCreated | 2000-12-27 | lld:pubmed |
| pubmed-article:11003165 | pubmed:abstractText | Water soluble 8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e]pyraz ine-4-one 4 represents a novel class of highly potent and selective AMPA receptors antagonists with in vivo activity. The dextrorotatory isomer (+)-4 was found to display the highest affinity with an IC50 of 10 nM. It also exhibited very good anticonvulsant effects after i.p., s.c. and i.v. administration in mice subjected to electrical convulsions (MES) and i.p. in audiogenic seizure-e in DBA/2 mice (ED50's < or = 10 mg/kg). | lld:pubmed |
| pubmed-article:11003165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11003165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11003165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11003165 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11003165 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:BoireauAA | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:PrattJJ | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:StutzmannJ... | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:MignaniSS | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:VuilhorgneMM | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:ImperatoAA | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:JimonetPP | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:RandleJ CJC | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:BohmeG AGA | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:DebonoM WMW | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:RibeillYY | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:DamourDD | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:ChevéMM | lld:pubmed |
| pubmed-article:11003165 | pubmed:author | pubmed-author:Genevois-Bore... | lld:pubmed |
| pubmed-article:11003165 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11003165 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11003165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11003165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11003165 | pubmed:pagination | 2211-7 | lld:pubmed |
| pubmed-article:11003165 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
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| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
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| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:meshHeading | pubmed-meshheading:11003165... | lld:pubmed |
| pubmed-article:11003165 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11003165 | pubmed:articleTitle | 8-Methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones: highly in vivo potent and selective AMPA receptor antagonists. | lld:pubmed |
| pubmed-article:11003165 | pubmed:affiliation | Aventis Pharma S.A., Centre de Recherche de Vitry-Alfortville, Vitry-sur-Seine, France. | lld:pubmed |
| pubmed-article:11003165 | pubmed:publicationType | Journal Article | lld:pubmed |
