| pubmed-article:10998138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10998138 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10998138 | lifeskim:mentions | umls-concept:C1511362 | lld:lifeskim |
| pubmed-article:10998138 | lifeskim:mentions | umls-concept:C0002171 | lld:lifeskim |
| pubmed-article:10998138 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10998138 | lifeskim:mentions | umls-concept:C0332162 | lld:lifeskim |
| pubmed-article:10998138 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10998138 | pubmed:dateCreated | 2000-10-20 | lld:pubmed |
| pubmed-article:10998138 | pubmed:abstractText | A murine CD44v10-neutralizing antibody has been reported to impair delayed-type hypersensitivity reactions. Because alopecia areata is characterized by a delayed-type hypersensitivity-like T cell mediated immune response, we addressed the question whether an anti-CD44v10-antibody influences the onset of alopecia areata. Therefore, we used the C3H/HeJ mouse model with the induction of alopecia areata in unaffected mice by the grafting of lesional alopecia areata mouse skin. Six grafted mice were injected (intraperitoneally) with anti-CD44v10, six grafted mice with anti-CD44standard, and six with phosphate-buffered saline only. After 11 wk phosphate-buffered saline injected animals on average had developed alopecia areata on 36.8% of their body. The onset of hair loss was slightly delayed and its extent reduced to 17.2% of their body in anti-CD44standard-treated mice. By contrast, five of six anti-CD44v10-treated mice did not show any hair loss and one mouse developed alopecia areata on only 1% of the body. Immunohistochemical examination revealed a marked reduction of perifollicular CD8+ lymphocytes and, to a lesser degree, CD4+ cells as well as a decreased expression of major histocompatibility complex class I on hair follicle epithelium in anti-CD44v10-treated mice as compared with phosphate-buffered saline or anti-CD44 standard-treated mice. Our data show that anti-CD44v10 is able to inhibit the onset of alopecia areata in C3H/HeJ mice. This might be accomplished by an anti-CD44v10-triggered impairment of immune cell homing (e.g., CD8+ T cells), resulting in a decrease of their number in target tissues. | lld:pubmed |
| pubmed-article:10998138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10998138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10998138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10998138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10998138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10998138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10998138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10998138 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10998138 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:ZieglerAA | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:HoffmannRR | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:KönigAA | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:ZöllerMM | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:HappleRR | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:SundbergJ PJP | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:SeiterSS | lld:pubmed |
| pubmed-article:10998138 | pubmed:author | pubmed-author:Freyschmidt-P... | lld:pubmed |
| pubmed-article:10998138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10998138 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:10998138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10998138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10998138 | pubmed:pagination | 653-7 | lld:pubmed |
| pubmed-article:10998138 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:meshHeading | pubmed-meshheading:10998138... | lld:pubmed |
| pubmed-article:10998138 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10998138 | pubmed:articleTitle | Treatment with an anti-CD44v10-specific antibody inhibits the onset of alopecia areata in C3H/HeJ mice. | lld:pubmed |
| pubmed-article:10998138 | pubmed:affiliation | Department of Dermatology and the Institute of Medical Biometry and Epidemiology, Philipp University, Marburg, Germany. freyschm@mailer.uni-marburg.de | lld:pubmed |
| pubmed-article:10998138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10998138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10998138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10998138 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10998138 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10998138 | lld:pubmed |
