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pubmed-article:10994952pubmed:abstractTextA new ion mobility/time-of-flight mass spectrometer employing a high-pressure MALDI source has been designed and tested. The prototype instrument operates at a source/drift cell pressure of 1-10 Torr helium, resulting in a mobility resolution of approximately 25. A small time-of-flight mass spectrometer (20 cm) with a mass resolution of up to 200 has been attached to the drift cell to identify (in terms of mass-to-charge ratio) the separated ions. A simple tripeptide mixture has been separated in the drift tube and mass identified as singly protonated species. The ability to separate peptide mixtures, e.g., tryptic digest of a protein, is illustrated and compared to results obtained on a high-vacuum time-of-flight instrument.lld:pubmed
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pubmed-article:10994952pubmed:pagination3965-71lld:pubmed
pubmed-article:10994952pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10994952pubmed:articleTitleCoupling high-pressure MALDI with ion mobility/orthogonal time-of-flight mass spectrometry.lld:pubmed
pubmed-article:10994952pubmed:affiliationDepartment of Chemistry, Texas A&M University, College Station 77843, USA.lld:pubmed
pubmed-article:10994952pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10994952pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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