| pubmed-article:10990540 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10990540 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:10990540 | pubmed:dateCreated | 2000-11-14 | lld:pubmed |
| pubmed-article:10990540 | pubmed:abstractText | We have investigated the effects of histamine on the intracellular calcium concentration ([Ca2+]i) of cultured rat cerebellar astrocytes using fura-2-based Ca2+ imaging microscopy. Most of the cells responded to the application of histamine with an increase in [Ca2+]i which was antagonized by the H1 receptor blocker mepyramine. When histamine was applied for several minutes, the majority of the cells displayed a biphasic Ca2+ response consisting of an initial transient peak and a sustained component. In contrast to the initial transient [Ca2+]i response, the sustained, receptor-activated increase in [Ca2+]i was rapidly abolished by chelation of extracellular Ca2+ or addition of Ni2+, Mn2+, Co2+ and Zn2+, but was unaffected by nifedipine, an antagonist of L-type voltage-activated Ca2+ channels. These data indicate that the sustained increase in [Ca2+]i was dependent on Ca2+ influx. When intracellular Ca2+ stores were emptied by prolonged application of histamine in Ca2+-free conditions, Ca2+ re-addition after removal of the agonist did not lead to an 'overshoot' of [Ca2+]i indicative of store-operated Ca2+ influx. However, Ca2+ stores were refilled despite the absence of any substantial change in the fura-2 signal. Depletion of intracellular Ca2+ stores using cyclopiazonic acid in Ca2+-free saline and subsequent re-addition of Ca2+ to the saline resulted in an increase in [Ca2+]i that was significantly enhanced in the presence of histamine. The results suggest that besides capacitative mechanisms, a non-capacitative, voltage-independent pathway is involved in histamine-induced Ca2+ entry into cultured rat cerebellar astrocytes. | lld:pubmed |
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| pubmed-article:10990540 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10990540 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10990540 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10990540 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10990540 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10990540 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:10990540 | pubmed:author | pubmed-author:DeitmerJ WJW | lld:pubmed |
| pubmed-article:10990540 | pubmed:author | pubmed-author:JungSS | lld:pubmed |
| pubmed-article:10990540 | pubmed:author | pubmed-author:PfeifferFF | lld:pubmed |
| pubmed-article:10990540 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10990540 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10990540 | pubmed:volume | 527 Pt 3 | lld:pubmed |
| pubmed-article:10990540 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10990540 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10990540 | pubmed:pagination | 549-61 | lld:pubmed |
| pubmed-article:10990540 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
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