| pubmed-article:10988346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C1180419 | lld:lifeskim |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C1513380 | lld:lifeskim |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:10988346 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10988346 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:10988346 | pubmed:dateCreated | 2000-10-10 | lld:pubmed |
| pubmed-article:10988346 | pubmed:abstractText | The pharmacological and molecular properties of ATP-sensitive K(+) channels present in pig detrusor smooth muscle were investigated. In isolated pig detrusor strips, ATP-sensitive K(+) channel openers inhibited contractions elicited by low frequency field-stimulation in a concentration-dependent manner. The inhibitory effects of P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N"-3-pyridylguanidine] were attenuated by glyburide with a pA(2) value of 7.38 (slope=1.08). The potency of the inhibitory effects of the K(+) channel openers on the field-stimulated contractions correlated well with those evoked by the muscarinic receptor agonist, carbachol (r=0.93) and furthermore, to relaxation of the pre-contracted (25 mM potassium chloride, KCl) human detrusor (r=0.95). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed the presence of mRNA for sulfonylurea receptors SUR1 and SUR2B in both pig and human detrusor. Considering the similarities in the molecular and pharmacological profile of ATP-sensitive K(+) channels between the pig and the human detrusor, it is concluded that the pig detrusor may serve as a suitable in vitro model for the evaluation of novel K(+) channel openers with potential use in urological disorders in humans. | lld:pubmed |
| pubmed-article:10988346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10988346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988346 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10988346 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10988346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10988346 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10988346 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:DazaAA | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:SullivanJ PJP | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:BrioniJ DJD | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:ScottV EVE | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:MilicicII | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:BucknerS ASA | lld:pubmed |
| pubmed-article:10988346 | pubmed:author | pubmed-author:Davis-TaberRR | lld:pubmed |
| pubmed-article:10988346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10988346 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10988346 | pubmed:volume | 400 | lld:pubmed |
| pubmed-article:10988346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10988346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10988346 | pubmed:pagination | 287-95 | lld:pubmed |
| pubmed-article:10988346 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10988346 | pubmed:meshHeading | pubmed-meshheading:10988346... | lld:pubmed |
| pubmed-article:10988346 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10988346 | pubmed:articleTitle | Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor. | lld:pubmed |
| pubmed-article:10988346 | pubmed:affiliation | Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, D47C, Bldg. AP9, First Floor, 100 Abbott Park Road, Abbott Park, IL 60064-6118, USA. steven.a.buckner@abbott.com | lld:pubmed |
| pubmed-article:10988346 | pubmed:publicationType | Journal Article | lld:pubmed |
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