| pubmed-article:10988328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0011602 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0221928 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0015252 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10988328 | lifeskim:mentions | umls-concept:C1326347 | lld:lifeskim |
| pubmed-article:10988328 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:10988328 | pubmed:dateCreated | 2000-10-10 | lld:pubmed |
| pubmed-article:10988328 | pubmed:abstractText | In the current study, a glycosaminoglycan lyase, chondroitinase B, was used to study the role of dermatan sulfate proteoglycans on human dermal fibroblast proliferation. Pretreatment with chondroitinase B significantly decreased fibroblast proliferative responses to serum (20% to 55%). In contrast, heparinase III and chondroitinase AC were less effective in inhibiting fibroblast proliferation to serum. Analysis of glycosaminoglycans on chondroitinase B-treated fibroblasts confirmed that dermatan sulfate was removed from fibroblasts by this enzyme. Chondroitinase B treatment also decreased proliferation to basic fibroblast growth factor (bFGF) by 20% and reduced receptor binding by 25%. Heparinase III inhibited bFGF binding by 73%, but decreased proliferation to bFGF by only 21%. Chondroitinase AC had no effect on bFGF proliferation or binding. These data suggest that dermatan sulfate proteoglycans play a significant role in the control of human dermal fibroblast proliferation. | lld:pubmed |
| pubmed-article:10988328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10988328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10988328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10988328 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10988328 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:10988328 | pubmed:author | pubmed-author:SilverP JPJ | lld:pubmed |
| pubmed-article:10988328 | pubmed:author | pubmed-author:DenholmE MEM | lld:pubmed |
| pubmed-article:10988328 | pubmed:author | pubmed-author:PoulinCC | lld:pubmed |
| pubmed-article:10988328 | pubmed:author | pubmed-author:CauchonEE | lld:pubmed |
| pubmed-article:10988328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10988328 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10988328 | pubmed:volume | 400 | lld:pubmed |
| pubmed-article:10988328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10988328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10988328 | pubmed:pagination | 145-53 | lld:pubmed |
| pubmed-article:10988328 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:meshHeading | pubmed-meshheading:10988328... | lld:pubmed |
| pubmed-article:10988328 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10988328 | pubmed:articleTitle | Inhibition of human dermal fibroblast proliferation by removal of dermatan sulfate. | lld:pubmed |
| pubmed-article:10988328 | pubmed:affiliation | Department of Cellular Biology, IBEX Pharmaceuticals, Inc., 5485 Pare, H4P 1P7, Montreal, Quebec, Canada. edenholm@ibexpharma.com | lld:pubmed |
| pubmed-article:10988328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10988328 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10988328 | lld:pubmed |
