| pubmed-article:10986340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C0815002 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C0030616 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C1424601 | lld:lifeskim |
| pubmed-article:10986340 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:10986340 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10986340 | pubmed:dateCreated | 2000-11-9 | lld:pubmed |
| pubmed-article:10986340 | pubmed:abstractText | Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridization and immunohistochemistry, we found that 19% to 37% of glutamic acid decarboxylase (GAD) expressing neurons co-expressed GFR alpha-1 in the hippocampus. GFR alpha-1/GAD co-expression was found mainly in the stratum (s) pyramidale (29-37%) and s. oriens (20-25%). Further characterization of GFR alpha-1 expressing interneurons, based on their calcium-binding protein immunoreactivity, demonstrated that many parvalbumin (PV) immunoreactive neurons express GFR alpha-1 in the s. pyramidale of CA1 (72%), CA2 (70%) and CA3 (70%) subfields of the hippocampus. GFR alpha-1/PV double labeled neurons were also detected in the s. oriens of CA1 (52%), CA2 (27%) and CA3 (36%) subfields. The expression of GFR alpha-1 in principal neurons and in a specific sub-population of GABAergic neurons (PV-containing neurons) suggest that GDNF might modulate, in a selective manner, functions of the entire adult hippocampus. | lld:pubmed |
| pubmed-article:10986340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10986340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10986340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10986340 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10986340 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:10986340 | pubmed:author | pubmed-author:HofferB JBJ | lld:pubmed |
| pubmed-article:10986340 | pubmed:author | pubmed-author:OlsonLL | lld:pubmed |
| pubmed-article:10986340 | pubmed:author | pubmed-author:MoralesMM | lld:pubmed |
| pubmed-article:10986340 | pubmed:author | pubmed-author:SarabiAA | lld:pubmed |
| pubmed-article:10986340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10986340 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:10986340 | pubmed:volume | 877 | lld:pubmed |
| pubmed-article:10986340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10986340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10986340 | pubmed:pagination | 262-70 | lld:pubmed |
| pubmed-article:10986340 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:meshHeading | pubmed-meshheading:10986340... | lld:pubmed |
| pubmed-article:10986340 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10986340 | pubmed:articleTitle | GFR alpha-1 is expressed in parvalbumin GABAergic neurons in the hippocampus. | lld:pubmed |
| pubmed-article:10986340 | pubmed:affiliation | National Institute on Drug Abuse, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:10986340 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10986340 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
