| pubmed-article:10982336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10982336 | lifeskim:mentions | umls-concept:C0935640 | lld:lifeskim |
| pubmed-article:10982336 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:10982336 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:10982336 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:10982336 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:10982336 | pubmed:dateCreated | 2000-10-4 | lld:pubmed |
| pubmed-article:10982336 | pubmed:abstractText | Baculovirus late RNAs are transcribed by a four-subunit RNA polymerase that is virus encoded. The late viral mRNAs are capped and polyadenylated, and we have previously shown that capping is mediated by the LEF-4 subunit of baculovirus RNA polymerase. Here we report studies undertaken to determine the mechanism of 3'-end formation. A globin cleavage/polyadenylation signal, which was previously shown to direct 3'-end formation of viral RNAs in vivo, was cloned into a baculovirus transcription template. In vitro assays with purified baculovirus RNA polymerase revealed that 3' ends were formed not by a cleavage mechanism but rather by termination after transcription of a T-rich region of the globin sequence. Terminated RNAs were released from ternary complexes and were subsequently polyadenylated. Mutational analyses indicated that the T-rich sequence was essential for termination and polyadenylation, but the poly(A) signal and the GT-rich region of the globin polyadenylation/cleavage signal were not required. Termination was not dependent on ATP hydrolysis, indicating a slippage mechanism. | lld:pubmed |
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| pubmed-article:10982336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10982336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10982336 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10982336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10982336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10982336 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10982336 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10982336 | pubmed:author | pubmed-author:GuarinoL ALA | lld:pubmed |
| pubmed-article:10982336 | pubmed:author | pubmed-author:JinJJ | lld:pubmed |
| pubmed-article:10982336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10982336 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10982336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10982336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10982336 | pubmed:pagination | 8930-7 | lld:pubmed |
| pubmed-article:10982336 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10982336 | pubmed:meshHeading | pubmed-meshheading:10982336... | lld:pubmed |
| pubmed-article:10982336 | pubmed:meshHeading | pubmed-meshheading:10982336... | lld:pubmed |
| pubmed-article:10982336 | pubmed:meshHeading | pubmed-meshheading:10982336... | lld:pubmed |
| pubmed-article:10982336 | pubmed:meshHeading | pubmed-meshheading:10982336... | lld:pubmed |
| pubmed-article:10982336 | pubmed:meshHeading | pubmed-meshheading:10982336... | lld:pubmed |
| pubmed-article:10982336 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10982336 | pubmed:articleTitle | 3'-end formation of baculovirus late RNAs. | lld:pubmed |
| pubmed-article:10982336 | pubmed:affiliation | Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA. | lld:pubmed |
| pubmed-article:10982336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10982336 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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