| pubmed-article:10979909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0579233 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0040555 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0206515 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C0205151 | lld:lifeskim |
| pubmed-article:10979909 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:10979909 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10979909 | pubmed:dateCreated | 2000-11-3 | lld:pubmed |
| pubmed-article:10979909 | pubmed:abstractText | An estimated 15% of invasive group B streptococcal (GBS) disease is caused by type II capsular polysaccharide (II CPS). In developing a pentavalent vaccine for the prevention of GBS infections, individual GBS CPSs have been coupled to tetanus toxoid (TT) to prepare vaccines with enhanced immunogenicity. Type II GBS (GBS II) vaccine was created by direct, covalent coupling of II CPS to TT by reductive amination. In 2 clinical trials, 75 healthy nonpregnant women 18-45 years old were randomized to receive II CPS-TT (II-TT) conjugate (dose range, 3.6-57 microg of CPS component) or uncoupled II CPS vaccine. Both vaccines were well tolerated. II CPS-specific IgG serum concentrations (as well as IgM and IgA) peaked 2 weeks after immunization, being significantly higher in recipients of conjugated vaccine than in recipients of uncoupled CPS. Immunological responses to conjugate were dose dependent and correlated with opsonophagocytosis in vitro. These results support inclusion of II-TT conjugate when preparing a multivalent GBS vaccine. | lld:pubmed |
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| pubmed-article:10979909 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10979909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10979909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10979909 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10979909 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:KasperD LDL | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:BakerC JCJ | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:HickmanM EME | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:PaolettiL CLC | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:GuttormsenH... | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:RenchM AMA | lld:pubmed |
| pubmed-article:10979909 | pubmed:author | pubmed-author:CareyV JVJ | lld:pubmed |
| pubmed-article:10979909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10979909 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:10979909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10979909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10979909 | pubmed:pagination | 1129-38 | lld:pubmed |
| pubmed-article:10979909 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10979909 | pubmed:meshHeading | pubmed-meshheading:10979909... | lld:pubmed |
| pubmed-article:10979909 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10979909 | pubmed:articleTitle | Use of capsular polysaccharide-tetanus toxoid conjugate vaccine for type II group B Streptococcus in healthy women. | lld:pubmed |
| pubmed-article:10979909 | pubmed:affiliation | Dept. of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. cbaker@bcm.tmc.edu | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:10979909 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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