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pubmed-article:10978213pubmed:dateCreated2000-10-31lld:pubmed
pubmed-article:10978213pubmed:abstractTextFlavonolignans represent natural compounds whose biosynthesis presumes a radical coupling of a ring B catecholic flavonoid with a molecule of coniferyl alcohol or an analogue. Many natural flavonolignans can exist as regioisomers, depending on how the coupled coniferyl alcohol moiety orients to the flavonoid. These regioisomers are often difficult to separate and have virtually identical NMR spectra. Structural assignments for some have changed with time or have been given without proof. We here report syntheses of both regioisomers of the flavonolignan hydnocarpin and one isomer of a plant isolate previously known as 5'-methoxyhydnocarpin. This isomer, here renamed 5'-methoxyhydnocarpin-D, was recently shown to be a potent inhibitor of a Staphylococcus aureus multidrug resistant efflux pump.lld:pubmed
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pubmed-article:10978213pubmed:authorpubmed-author:StermitzF RFRlld:pubmed
pubmed-article:10978213pubmed:authorpubmed-author:GuzN RNRlld:pubmed
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pubmed-article:10978213pubmed:volume63lld:pubmed
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pubmed-article:10978213pubmed:pagination1140-5lld:pubmed
pubmed-article:10978213pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10978213pubmed:year2000lld:pubmed
pubmed-article:10978213pubmed:articleTitleSynthesis and structures of regioisomeric hydnocarpin-type flavonolignans.lld:pubmed
pubmed-article:10978213pubmed:affiliationDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.lld:pubmed
pubmed-article:10978213pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10978213pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:10978213pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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