| pubmed-article:10975864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C2698599 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C0104998 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C0235914 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C1705431 | lld:lifeskim |
| pubmed-article:10975864 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10975864 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10975864 | pubmed:dateCreated | 2000-10-10 | lld:pubmed |
| pubmed-article:10975864 | pubmed:abstractText | The activation of T lymphocytes requires both Ag-mediated signaling through the TCR as well as costimulatory signals transmitted through B7-1 and/or B7-2 with CD28. The interference of B7-mediated costimulatory signals has been proposed as one immunotherapeutic intervention for the prevention autoimmune disease. This study has examined autoantibody responses and autoimmune pathology in a murine model of human systemic lupus erythematosus (SLE), the MRL-lpr/lpr mouse, genetically deficient in B7-1 or B7-2, or in mice treated with B7-1/B7-2 blocking Abs. In contrast to other studies of murine models of SLE, MRL-lpr/lpr mice treated with B7 blocking Abs exhibit strong anti-small nuclear ribonucleoprotein (snRNP) and anti-DNA autoantibody responses with some changes in isotype switching as compared with untreated animals. All MRL-lpr/lpr mice deficient in B7-1 or B7-2 produce anti-snRNP and anti-DNA titers with isotypes virtually identical with wild-type animals. However, the absence of B7-2 costimulation did interfere with the spontaneous activation and the accumulation of memory CD4+ or CD8+ T lymphocytes characteristic of wild-type MRL-lpr/lpr mice. IgG and C3 complement deposition was less pronounced in the kidneys of B7-2 deficient MRL-lpr/lpr mice, reflecting their lessor degree of glomerulonephritis. By comparison, B7-1-deficient MRL-lpr/lpr mice had more severe IgG and C3 deposits in glomeruli. | lld:pubmed |
| pubmed-article:10975864 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10975864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975864 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10975864 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10975864 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10975864 | pubmed:author | pubmed-author:LiangBB | lld:pubmed |
| pubmed-article:10975864 | pubmed:author | pubmed-author:SharpeA HAH | lld:pubmed |
| pubmed-article:10975864 | pubmed:author | pubmed-author:MamulaM JMJ | lld:pubmed |
| pubmed-article:10975864 | pubmed:author | pubmed-author:KashgarianM... | lld:pubmed |
| pubmed-article:10975864 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10975864 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10975864 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:10975864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10975864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10975864 | pubmed:pagination | 3436-43 | lld:pubmed |
| pubmed-article:10975864 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10975864 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10975864 | pubmed:articleTitle | Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus. | lld:pubmed |
| pubmed-article:10975864 | pubmed:affiliation | Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:10975864 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10975864 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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