Linked Life Data

10975736

Source:http://linkedlifedata.com/resource/pubmed/id/10975736

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pubmed-article:10975736pubmed:abstractTextThis study was aimed at analyzing the changes in cutaneous sensory corpuscles from the territory of lesioned nerves and clinically denervated skin of patients with spinal cord injury using immunohistochemical methods. The morphological and biochemical characteristics of the Schwann-related cells of the mature sensory corpuscles (lamellar cells of Meissner corpuscles and inner-core of Pacinian corpuscles) depend upon the axon. To clarify whether this dependence requires structural and/or functional integrity of sensory axons we analyzed immunohistochemically some axonal, Schwann cell and perineurial cell antigens in cutaneous sensory corpuscles from i) the underlesional levels of patients with spinal cord injury affecting dorsal and lateral funiculi; ii) peripheral nerve entrapment, iii) sectioned and grafted nerves. Skin biopsy samples from the hand or feet were processed for peroxidase-antiperoxidase immunohistochemistry using monoclonal antibodies directed against neurofilament proteins (to label the axons), S-100 protein (to label Schwann-related cells), epithelial membrane antigen (to label the perineurial derivatives), vimentin (to label both Schwann cell and perineurial derivatives). Meissner and Pacinian corpuscles of subjects suffering from spinal cord lesions showed an immunohistochemical profile close to normality, although in many of them S-100 protein was unevenly distributed or absent. Sensory corpuscles of the cutaneous territory of entrapped nerves were in most cases similar to those of normally innervated skin. The most striking finding in these subjects was the hyperinnervation of blood vessels and sweat glands. Finally, nerve section and subsequent unsuccessful graft repair resulted in absence of immunostaining for all the assessed antigens in sensory corpuscles. The present results suggest that structural, but not functional, integrity of the axon is essential in maintaining some immunohistochemical characteristics of the human cutaneous sensory corpuscles. Morphological findings are correlated and discussed in relation to the clinical evaluation of the sensitivity.lld:pubmed
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pubmed-article:10975736pubmed:authorpubmed-author:MárquezJJlld:pubmed
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pubmed-article:10975736pubmed:pagination49-59lld:pubmed
pubmed-article:10975736pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:10975736pubmed:articleTitleEffect of spinal cord and peripheral nerve injury on human cutaneous sensory corpuscles. An immunohistochemical study.lld:pubmed
pubmed-article:10975736pubmed:affiliationServicio de Cirugía Plástica y Reparadora, Hospital Central de Asturias, Oviedo, Spain.lld:pubmed
pubmed-article:10975736pubmed:publicationTypeJournal Articlelld:pubmed