| pubmed-article:10975519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C0014181 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C1704319 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C0019647 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C0031678 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C1420464 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C1418858 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C2346566 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:10975519 | lifeskim:mentions | umls-concept:C0296603 | lld:lifeskim |
| pubmed-article:10975519 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10975519 | pubmed:dateCreated | 2000-9-19 | lld:pubmed |
| pubmed-article:10975519 | pubmed:abstractText | Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In these models, both enzymes are required for H3 phosphorylation and chromosome segregation, although a causal link between the two processes has not been demonstrated. Deregulation of human aurora kinases has been implicated in oncogenesis as a consequence of chromosome missegregation. Our findings reveal an enzyme system that regulates chromosome dynamics and controls histone phosphorylation that is conserved among diverse eukaryotes. | lld:pubmed |
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| pubmed-article:10975519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10975519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10975519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10975519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10975519 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10975519 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:SmithM MMM | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:LieKK | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:AllisC DCD | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:TatchellKK | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:HuntD FDF | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:LULL | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:HsuJ YJY | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:BishopD KDK | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:SunZ WZW | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:ReubenMM | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:CaldwellJ AJA | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:BrameC JCJ | lld:pubmed |
| pubmed-article:10975519 | pubmed:author | pubmed-author:GrushcowJ MJM | lld:pubmed |
| pubmed-article:10975519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10975519 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:10975519 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:10975519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10975519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10975519 | pubmed:pagination | 279-91 | lld:pubmed |
| pubmed-article:10975519 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
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| pubmed-article:10975519 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10975519 | pubmed:articleTitle | Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. | lld:pubmed |
| pubmed-article:10975519 | pubmed:affiliation | Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA. | lld:pubmed |
| pubmed-article:10975519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10975519 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10975519 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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