| pubmed-article:10973451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C1136218 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0021270 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0682053 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:10973451 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10973451 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10973451 | pubmed:dateCreated | 2000-10-20 | lld:pubmed |
| pubmed-article:10973451 | pubmed:abstractText | A new meningococcal group C-CRM(197) conjugate vaccine (MnCC; Meningitec) has been evaluated in multiple clinical trials in the United States and most recently has been approved for routine administration in the United Kingdom. Meningococcal serogroup C (MnC)-specific immunoglobulin G (IgG) antibodies in pre- and postimmunization sera obtained from healthy U.S. adults, toddlers, and infants were quantitated by enzyme-linked immunosorbent assay (ELISA) and by an antibody-dependent, complement-mediated serum bactericidal assay (SBA). Serogroup-specific IgG antibody (micrograms per milliliter) in adults immunized either with the quadrivalent polysaccharide (A, C, Y, and W-135) vaccine or with MnCC showed a strong correlation (r = 0.848 and 0.934, respectively) by linear regression analysis with SBA. Sera from infants immunized with the MnCC (n = 30) and an age-matched unimmunized control group (n = 15) were also analyzed. Linear regression analysis of serum bactericidal and IgG ELISA data from sera obtained at 2 months of age (preimmunization) showed no correlation; however, a high degree of correlation was observed at time points after two (r = 0.877) and three (r = 0.951) immunizations, where significant rises in anti-MnC polysaccharide antibodies occurred relative to the age-matched control group. Infants previously primed with 3 doses of MnCC were given a booster dose of conjugate vaccine at 12 to 15 months of age. The correlation coefficient of ELISA to SBA for combined pre- and postbooster data was r = 0.836 (n = 48 pairs). In conclusion, increases in serum bactericidal activity in immunized adult, toddler, and infant populations were found to correlate very well with increases in serogroup-specific IgG concentrations, whereas the correlation between these two assays in nonimmunized 2-month-old infants was poor. Characterizing the relationship between these methods is important for understanding the significance of antigen-specific antibody concentrations relative to vaccine performance and protection from disease. | lld:pubmed |
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| pubmed-article:10973451 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10973451 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10973451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10973451 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10973451 | pubmed:issn | 1071-412X | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:KimuraAA | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:HildrethS WSW | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:SikkemaD JDJ | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:MadoreD VDV | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:QuataertS ASA | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:FriedmanK EKE | lld:pubmed |
| pubmed-article:10973451 | pubmed:author | pubmed-author:CorsaroBB | lld:pubmed |
| pubmed-article:10973451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10973451 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:10973451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10973451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10973451 | pubmed:pagination | 764-8 | lld:pubmed |
| pubmed-article:10973451 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10973451 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10973451 | pubmed:articleTitle | Relationship between serum bactericidal activity and serogroup-specific immunoglobulin G concentration for adults, toddlers, and infants immunized with Neisseria meningitidis serogroup C vaccines. | lld:pubmed |
| pubmed-article:10973451 | pubmed:affiliation | Wyeth-Lederle Vaccines and Pediatrics, West Henrietta, New York 14586, USA. sikkemad@war.wyeth.com | lld:pubmed |
| pubmed-article:10973451 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10973451 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10973451 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:10973451 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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