| pubmed-article:10968790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C1166825 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C1416380 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10968790 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:10968790 | pubmed:issue | 5484 | lld:pubmed |
| pubmed-article:10968790 | pubmed:dateCreated | 2000-9-14 | lld:pubmed |
| pubmed-article:10968790 | pubmed:abstractText | Activation of the transcription factor nuclear factor (NF)-kappaB by proinflammatory stimuli leads to increased expression of genes involved in inflammation. Activation of NF-kappaB requires the activity of an inhibitor of kappaB (IkappaB)-kinase (IKK) complex containing two kinases (IKKalpha and IKKbeta) and the regulatory protein NEMO (NF-kappaB essential modifier). An amino-terminal alpha-helical region of NEMO associated with a carboxyl-terminal segment of IKKalpha and IKKbeta that we term the NEMO-binding domain (NBD). A cell-permeable NBD peptide blocked association of NEMO with the IKK complex and inhibited cytokine-induced NF-kappaB activation and NF-kappaB-dependent gene expression. The peptide also ameliorated inflammatory responses in two experimental mouse models of acute inflammation. The NBD provides a target for the development of drugs that would block proinflammatory activation of the IKK complex without inhibiting basal NF-kappaB activity. | lld:pubmed |
| pubmed-article:10968790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10968790 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10968790 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10968790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10968790 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10968790 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:GhoshSS | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:PoberJ SJS | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:GlöcknerJJ | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:ACPP | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:D'AcquistoFF | lld:pubmed |
| pubmed-article:10968790 | pubmed:author | pubmed-author:MadgeL ALA | lld:pubmed |
| pubmed-article:10968790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10968790 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10968790 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:10968790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10968790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10968790 | pubmed:pagination | 1550-4 | lld:pubmed |
| pubmed-article:10968790 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10968790 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10968790 | pubmed:articleTitle | Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. | lld:pubmed |
| pubmed-article:10968790 | pubmed:affiliation | Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:10968790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10968790 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10968790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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