| pubmed-article:1096801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0005507 | lld:lifeskim |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0002679 | lld:lifeskim |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0016278 | lld:lifeskim |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:1096801 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:1096801 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1096801 | pubmed:dateCreated | 1975-10-7 | lld:pubmed |
| pubmed-article:1096801 | pubmed:abstractText | It is important that serum levels of 5-fluorocytosine (5FC) be measured to insure therapeutic levels while avoiding toxicity. This is particularly true in patients with renal insufficiency. The concurrent use of amphotericin B and 5FC complicates the measurement of 5FC in the serum, since fungi used in conventional bioassay systems are uniformly susceptible to amphotericin B. This paper describes the development of a simple, reliable, 6-h bioassay for 5FC in the presence of amphotericin B. The assay is based upon the fact that 5FC diffuses readily through yeast nitrogen base agar, whereas amphotericin B apparently does not. This assay allows rapid adjustments in therapy of patients receiving both 5FC and amphotericin B and has permitted us to maintain 5FC serum levels between limits of 25 and 120 mug/ml in patients with altered renal function. | lld:pubmed |
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| pubmed-article:1096801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1096801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1096801 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1096801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1096801 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1096801 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:1096801 | pubmed:author | pubmed-author:DrutzD JDJ | lld:pubmed |
| pubmed-article:1096801 | pubmed:author | pubmed-author:KasparR LRL | lld:pubmed |
| pubmed-article:1096801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1096801 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:1096801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1096801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1096801 | pubmed:pagination | 462-5 | lld:pubmed |
| pubmed-article:1096801 | pubmed:dateRevised | 2010-9-3 | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:meshHeading | pubmed-meshheading:1096801-... | lld:pubmed |
| pubmed-article:1096801 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1096801 | pubmed:articleTitle | Rapid, simple bioassay for 5-fluorocytosine in the presence of amphotericin B. | lld:pubmed |
| pubmed-article:1096801 | pubmed:publicationType | Journal Article | lld:pubmed |
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