| pubmed-article:10967121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10967121 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10967121 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:10967121 | lifeskim:mentions | umls-concept:C0069139 | lld:lifeskim |
| pubmed-article:10967121 | lifeskim:mentions | umls-concept:C1660642 | lld:lifeskim |
| pubmed-article:10967121 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:10967121 | pubmed:dateCreated | 2000-12-29 | lld:pubmed |
| pubmed-article:10967121 | pubmed:abstractText | Nucleolin functions in ribosome biogenesis and contains an acidic N terminus that binds nuclear localization sequences. In previous work we showed that human nucleolin associates with the N-terminal region of human topoisomerase I (Top1). We have now mapped the topoisomerase I interaction domain of nucleolin to the N-terminal 225 amino acids. We also show that the Saccharomyces cerevisiae nucleolin ortholog, Nsr1p, physically interacts with yeast topoisomerase I, yTop1p. Studies of isogenic NSR1(+) and Deltansr1 strains indicate that NSR1 is important in determining the cellular localization of yTop1p. Moreover, deletion of NSR1 reduces sensitivity to camptothecin, an antineoplastic topoisomerase I inhibitor. By contrast, Deltansr1 cells are hypersensitive to the topoisomerase II-targeting drug amsacrine. These findings indicate that nucleolin/Nsr1 is involved in the cellular localization of Top1 and that this localization may be important in determining sensitivity to drugs that target topoisomerases. | lld:pubmed |
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| pubmed-article:10967121 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10967121 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10967121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10967121 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10967121 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:RubinE HEH | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:SaleemAA | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:DennisTT | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:EdwardsT KTK | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:GartenbergM... | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:OliverosEE | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:GerigkCC | lld:pubmed |
| pubmed-article:10967121 | pubmed:author | pubmed-author:ShamanJ AJA | lld:pubmed |
| pubmed-article:10967121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10967121 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10967121 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10967121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10967121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10967121 | pubmed:pagination | 36181-8 | lld:pubmed |
| pubmed-article:10967121 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10967121 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10967121 | pubmed:articleTitle | Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I. | lld:pubmed |
| pubmed-article:10967121 | pubmed:affiliation | Departments of Medicine/Pharmacology, Cancer Institute of New Jersey/Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA. | lld:pubmed |
| pubmed-article:10967121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10967121 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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