| pubmed-article:10965892 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0120489 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0249083 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10965892 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10965892 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10965892 | pubmed:dateCreated | 2000-9-21 | lld:pubmed |
| pubmed-article:10965892 | pubmed:abstractText | Members of the receptor-guanylate cyclase (rGC) family possess an intracellular catalytic domain that is regulated by an extracellular receptor domain. GC-C, an intestinally expressed rGC, was initially cloned by homology as an orphan receptor. The search for its ligands has yielded three candidates: STa (a bacterial toxin that causes traveler's diarrhea) and the endogenous peptides uroguanylin and guanylin. Here, by performing Northern and Western blots, and by measuring [125I]STa binding and STa-dependent elevation of cGMP levels, we investigate whether the distribution of GC-C matches that of its endogenous ligands in the rat intestine. We establish that 1) uroguanylin is essentially restricted to small bowel; 2) guanylin is very low in proximal small bowel, increasing to prominent levels in distal small bowel and throughout colon; 3) GC-C messenger RNA and STa-binding sites are uniformly expressed throughout the intestine; and 4) GC-C-mediated cGMP synthesis peaks at the proximal and distal extremes of the intestine (duodenum and colon), but is nearly absent in the middle (ileum). These observations suggest that GC-C's activity may be posttranslationally regulated, demonstrate that the distribution of GC-C is appropriate to mediate the actions of both uroguanylin and guanylin, and help to refine current hypotheses about the physiological role(s) of these peptides. | lld:pubmed |
| pubmed-article:10965892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10965892 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10965892 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10965892 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10965892 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:10965892 | pubmed:author | pubmed-author:GoyM FMF | lld:pubmed |
| pubmed-article:10965892 | pubmed:author | pubmed-author:QianXX | lld:pubmed |
| pubmed-article:10965892 | pubmed:author | pubmed-author:PrabhakarSS | lld:pubmed |
| pubmed-article:10965892 | pubmed:author | pubmed-author:VisweswariahS... | lld:pubmed |
| pubmed-article:10965892 | pubmed:author | pubmed-author:NandiAA | lld:pubmed |
| pubmed-article:10965892 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10965892 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:10965892 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10965892 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10965892 | pubmed:pagination | 3210-24 | lld:pubmed |
| pubmed-article:10965892 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
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| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
| pubmed-article:10965892 | pubmed:meshHeading | pubmed-meshheading:10965892... | lld:pubmed |
| pubmed-article:10965892 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10965892 | pubmed:articleTitle | Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine. | lld:pubmed |
| pubmed-article:10965892 | pubmed:affiliation | Department of Cell and Molecular Physiology, University of North Carolina, Chaptel Hill 27599-7545, USA. | lld:pubmed |
| pubmed-article:10965892 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10965892 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10965892 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10965892 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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