Linked Life Data

10965494

Source:http://linkedlifedata.com/resource/pubmed/id/10965494

Statements in which the resource exists.
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pubmed-article:10965494pubmed:abstractTextCertain gene therapy protocols may require multiple administrations of vectors to achieve therapeutic benefit to the patient. This may be especially relevant for vectors such as adenoviral vectors that do not integrate into the host chromosome. Because immunocompetent animal models used for gene transfer studies develop neutralizing antibodies to adenoviral vectors after a single administration, little is known about how repeat administrations of vectors might affect transgene expression and vector toxicity.lld:pubmed
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pubmed-article:10965494pubmed:articleTitleToxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.lld:pubmed
pubmed-article:10965494pubmed:affiliationDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. woneal@email.unc.edulld:pubmed
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pubmed-article:10965494pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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