Linked Life Data

10960162

Source:http://linkedlifedata.com/resource/pubmed/id/10960162

Statements in which the resource exists.
SubjectPredicateObjectContext
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pubmed-article:10960162pubmed:abstractTextWe examined two methods of generating a dose-response curve to the opioid receptor antagonist naloxone. In 15 healthy male subjects (18-25 years) plasma adrenocorticotropin (ACTH) responses to five doses of naloxone studied over 5 separate days were compared to plasma ACTH responses to five incremental doses of naloxone studied within a single session. There was a statistically significant positive correlation in ACTH responses (area under the curve and peak) between dosing methods. Furthermore, the doses of naloxone that produced half-maximal and maximal ACTH response were similar. The comparability of ACTH responses between the two naloxone dosing techniques, combined with the safety and ease associated with the single-session methodology, underscores the usefulness of the single-session technique for future investigations.lld:pubmed
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pubmed-article:10960162pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10960162pubmed:articleTitlePlasma adrenocorticotropin responses to opioid blockade with naloxone: generating a dose-response curve in a single session.lld:pubmed
pubmed-article:10960162pubmed:affiliationThe Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.lld:pubmed
pubmed-article:10960162pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10960162pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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