| pubmed-article:10954328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10954328 | lifeskim:mentions | umls-concept:C0034143 | lld:lifeskim |
| pubmed-article:10954328 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:10954328 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10954328 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:10954328 | lifeskim:mentions | umls-concept:C0063217 | lld:lifeskim |
| pubmed-article:10954328 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10954328 | pubmed:dateCreated | 2000-11-21 | lld:pubmed |
| pubmed-article:10954328 | pubmed:abstractText | Whole-cell, patch-clamp recordings from acutely isolated cerebellar Purkinje neurons demonstrate a two-stage modulation of P-type high-voltage-activated (HVA) Ca2+ current by a constituent of St. John's wort, hyperforin (0.04-0.8 microM). The first stage of modulation was voltage dependent and reversible. It comprised slow-down of the activation kinetics and a shift in the voltage dependence of P-current to more negative voltages. Hyperforin (0.8 microM) shifted the maximum of the current/voltage (I/V) relationship by -8+/-2 mV. The second, voltage-independent stage of modulation was manifested as a slowly developing inhibition of P-current that could not be reversed within the period of study. Neither form of modulation was abolished by intracellular guanosine 5'-O-(2-thiodiphosphate) (GDPPS) or guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) or by strong depolarising pre-pulses, indicating that modulation via guanine nucleotide-binding proteins (G proteins) is not involved in the observed phenomenon. Calmidazolium (0.5 microM), an antagonist of the intracellular Ca2+-binding protein calmodulin significantly inhibited the hyperforin-induced shift of the IIV curve maximum and the slow-down of the activation kinetics. It did not, however, affect the delayed inhibition of P-current, indicating that the two stages of modulation are mediated by separate mechanisms. | lld:pubmed |
| pubmed-article:10954328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10954328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10954328 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10954328 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:ChatterjeeSS | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:KrishtalOO | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:LozovayaNN | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:NöldnerMM | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:TsintsadzeTT | lld:pubmed |
| pubmed-article:10954328 | pubmed:author | pubmed-author:FisunovAA | lld:pubmed |
| pubmed-article:10954328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10954328 | pubmed:volume | 440 | lld:pubmed |
| pubmed-article:10954328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10954328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10954328 | pubmed:pagination | 427-34 | lld:pubmed |
| pubmed-article:10954328 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10954328 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10954328 | pubmed:articleTitle | Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. | lld:pubmed |
| pubmed-article:10954328 | pubmed:affiliation | Department of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, Ukraine. | lld:pubmed |
| pubmed-article:10954328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10954328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
